Universität zu Köln

Sun, Xue ORCID: 0000-0001-9234-561X, Veldhuizen, Maria G., Wray, Amanda E., de Araujo, Ivan E., Sherwin, Robert S., Sinha, Rajita and Small, Dana M. (2014). The neural signature of satiation is associated with ghrelin response and triglyceride metabolism. Physiol. Behav., 136. S. 63 - 74. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 0031-9384

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Abstract

Eating behavior is guided by a complex interaction between signals conveying information about energy stores, food availability, and palatability. How peripheral signals regulate brain circuits that guide feeding during sensation and consumption of a palatable food is poorly understood. We used NM to measure brain response to a palatable food (milkshake) when n = 32 participants were fasted and fed with either a fixed-portion or ad libitum meal. We found that larger post-prandial reductions in ghrelin and increases in triglycerides were associated with greater attenuation of response to the milkshake in brain regions regulating reward and feeding including the midbrain, amygdala, pallidum, hippocampus, insula and medial orbitofrontal cortex. Satiation-induced brain responses to milkshake were not related to acute changes in circulating insulin, glucose, or free fatty adds. The impact of a meal on the response to milkshake in the midbrain and dorsolateral prefrontal cortex differed depending upon whether meal termination was fixed or volitional, irrespective of the amount of food consumed. We conclude that satiation-induced changes in brain response to a palatable food are strongly and specifically associated with changes in circulating ghrelin and triglycerides and by volitional meal termination. (C) 2014 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sun, Xue UNSPECIFIED orcid.org/0000-0001-9234-561X UNSPECIFIED Veldhuizen, Maria G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wray, Amanda E. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Araujo, Ivan E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sherwin, Robert S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sinha, Rajita UNSPECIFIED UNSPECIFIED UNSPECIFIED Small, Dana M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-429141
DOI:	10.1016/j.physbeh.2014.04.017
Journal or Publication Title:	Physiol. Behav.
Volume:	136
Page Range:	S. 63 - 74
Date:	2014
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	0031-9384
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN ORBITOFRONTAL CORTEX; BODY-WEIGHT REGULATION; FTO GENE; BRAIN ACTIVITY; ENERGY-INTAKE; FOOD-INTAKE; PREFRONTAL CORTEX; VENTRAL STRIATUM; HUMAN AMYGDALA; EXTERNAL CUES Multiple languages Psychology, Biological; Behavioral Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42914