Universität zu Köln

Vehreschild, J. J., Boehme, A., Cornely, O. A., Kahl, C., Karthaus, M., Kreuzer, K. -A., Maschmeyer, G., Mousset, S., Ossendorf, V., Penack, O., Vehreschild, M. J. G. T. and Bohlius, J. (2014). Prophylaxis of infectious complications with colony-stimulating factors in adult cancer patients undergoing chemotherapy-evidence-based guidelines from the Infectious Diseases Working Party AGIHO of the German Society for Haematology and Medical Oncology (DGHO). Ann. Oncol., 25 (9). S. 1709 - 1720. OXFORD: OXFORD UNIV PRESS. ISSN 1569-8041

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Abstract

Background: Current evidence on myelopoietic growth factors is difficult to overview for the practicing haematologist/oncologist. International guidelines are sometimes conflicting, exclude certain patient groups, or cannot directly be applied to the German health system. This guideline by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO) gives evidence-based recommendations for the use of G-CSF, pegylated G-CSF, and biosimilars to prevent infectious complications in cancer patients undergoing chemotherapy, including those with haematological malignancies. Methods: We systematically searched and evaluated current evidence. An expert panel discussed the results and recommendations. We then compared our recommendations to current international guidelines. Results: We summarised the data from eligible studies in evidence tables, developed recommendations for different entities and risk groups. Conclusion: Comprehensive literature search and expert panel consensus confirmed many key recommendations given by international guidelines. Evidence for growth factors during acute myeloid leukaemia induction chemotherapy and pegfilgrastim use in haematological malignancies was rated lower compared with other guidelines.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vehreschild, J. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boehme, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kahl, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karthaus, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuzer, K. -A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maschmeyer, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mousset, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ossendorf, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Penack, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, M. J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bohlius, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-429858
DOI:	10.1093/annonc/mdu035
Journal or Publication Title:	Ann. Oncol.
Volume:	25
Number:	9
Page Range:	S. 1709 - 1720
Date:	2014
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1569-8041
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; NON-HODGKINS-LYMPHOMA; CELL LUNG-CANCER; INDUCED FEBRILE NEUTROPENIA; ACUTE MYELOGENOUS LEUKEMIA; SINGLE-ADMINISTRATION PEGFILGRASTIM; RISK MYELODYSPLASTIC SYNDROMES; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42985