Universität zu Köln

Bausewein, Claudia ORCID: 0000-0002-0958-3041 and Simon, Steffen T. (2014). Inhaled nebulized and intranasal opioids for the relief of breathlessness. Curr. Opin Support Palliat. Car., 8 (3). S. 208 - 213. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1751-4266

Full text not available from this repository.

Abstract

Purpose of review Inhaled nebulized and intranasal opioid administration is available with a proven short onset of action for the relief of pain. As breathlessness episodes are short, these routes of administration seem to be attractive for breathlessness management. This review describes the recent studies evaluating the effectiveness of inhaled nebulized and intranasal application of opioids for patients suffering from refractory breathlessness. Recent findings Since 2012, one systematic review and three primary studies have been identified. The systematic review summarized five studies including seventy patients testing nebulized fentanyl and two studies including five patients evaluating intranasal application. Two randomized controlled trials tested inhaled fentanyl or morphine and one retrospective chart review described the application of intranasal fentanyl in newborn babies. Inhaled fentanyl did not improve the intensity or unpleasantness of perceived dyspnea, but the rate of increase in dyspnea intensity and unpleasantness ratings between isotime and peak exercise was less after treatment with fentanyl. Inhaled morphine improved breathlessness in chronic obstructive pulmonary disease patients. Summary There is currently not enough evidence to support the use of inhaled application of opioids for the relief of breathlessness. There are no controlled trials assessing the efficacy and effectiveness of intranasal opioid application, but a pilot trial is underway to provide preliminary data.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bausewein, Claudia UNSPECIFIED orcid.org/0000-0002-0958-3041 UNSPECIFIED Simon, Steffen T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-430806
DOI:	10.1097/SPC.0000000000000071
Journal or Publication Title:	Curr. Opin Support Palliat. Car.
Volume:	8
Number:	3
Page Range:	S. 208 - 213
Date:	2014
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1751-4266
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FENTANYL CITRATE; DIFFERENT ROUTES; DOUBLE-BLIND; DYSPNEA; MORPHINE; CANCER; DISEASE; LUNG; PHARMACOKINETICS; BIOAVAILABILITY Multiple languages Health Care Sciences & Services Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43080