Universität zu Köln

Yan, Jing, Xu, Yan, Hu, Brian, Alnajm, Sammy, Liu, Lina, Lu, Yin, Sun, Zhiguang and Cheng, Feng ORCID: 0000-0003-3619-8090 (2014). TIBS: A web database to browse gene expression in irritable bowel syndrome. J. Theor. Biol., 354. S. 48 - 54. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1095-8541

Full text not available from this repository.

Abstract

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder. Its symptoms include chronic abdominal pain, bloating gas, diarrhea and constipation. Many IBS patients also have psychological symptoms like depression or anxiety. These unpleasant symptoms significantly lower patients' quality of life. The prevalence of IBS in Europe and North America is about 10-15% of the population, which makes IBS a disorder with a high social cost The pathophysiology of IBS is considered to be multifactorial and the exact cause of the disease remains poorly understood. Recently, a genome-wide expression microarray tedinique has been applied to investigate the possible mechanisms of IBS. However, a user-friendly database that allows scientists without bioinformatics background to query gene expression levels in these data sets and compare gene expression patterns across different tissues has not yet been established. Therefore, we have integrated four public expression microanzy data (320 samples) from the Gene Expression Omnibus (GEO) and ArrayExpress databases into an online database called Transcriptome of Irritable Bowel Syndrome (TIBS). The gene expression change in IBS patients compared to healthy volunteers or UC patients in jejunum, sigmoid colon, rectum, and descending colon can be queried by gene symbols. Users can compare gene expression levels of IBS patients across these tissues. Sex difference of gene expression in IBS patients was also shown in the database. The current version of TIBS database contains 42,400 annotated gene probe sets represented on the Affymetrix Human Genome U133 plus 2.0 platform. TIBS will be an invaluable resource for a better understanding of the pathogenesis of IBS at the molecular level and for drug development The TIBS database is available online at http://www.chengfeng.infoitibs_database.html. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yan, Jing UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Yan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Brian UNSPECIFIED UNSPECIFIED UNSPECIFIED Alnajm, Sammy UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Lina UNSPECIFIED UNSPECIFIED UNSPECIFIED Lu, Yin UNSPECIFIED UNSPECIFIED UNSPECIFIED Sun, Zhiguang UNSPECIFIED UNSPECIFIED UNSPECIFIED Cheng, Feng UNSPECIFIED orcid.org/0000-0003-3619-8090 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-432120
DOI:	10.1016/j.jtbi.2014.03.026
Journal or Publication Title:	J. Theor. Biol.
Volume:	354
Page Range:	S. 48 - 54
Date:	2014
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1095-8541
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-DISEASE; PREDICTION; RESPONSES; PROTEINS; IDENTIFY; TRACT Multiple languages Biology; Mathematical & Computational Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43212