Universität zu Köln

Schieck, Elise ORCID: 0000-0003-1756-6337, Liljander, Anne, Hamsten, Carl, Gicheru, Nimmo, Scacchia, Massimo ORCID: 0000-0002-0013-9788, Sacchini, Flavio ORCID: 0000-0003-2618-6192, Heller, Martin, Schnee, Christiane, Sterner-Kock, Anja, Hlinak, Andreas, Naessens, Jan, Poole, Jane, Persson, Anja and Jores, Joerg ORCID: 0000-0003-3790-5746 (2014). High antibody titres against predicted Mycoplasma surface proteins do not prevent sequestration in infected lung tissue in the course of experimental contagious bovine pleuropneumonia. Vet. Microbiol., 172 (1-2). S. 285 - 294. AMSTERDAM: ELSEVIER. ISSN 1873-2542

Full text not available from this repository.

Abstract

Contagious bovine pleuropneumonia (CBPP), a severe respiratory disease of cattle caused by Mycoplasma mycoides subsp. mycoides (Mmm) is endemic in many African countries due to fragmented veterinary services and the lack of an efficient vaccine and sensitive diagnostics. More efficient tools to control the disease are needed, but to develop the tools, a better understanding of host-pathogen interactions is necessary. The aim of this study was to characterize the kinetics of the humoral immune response against 65 Mmm surface antigens for an extended period in cattle that survived a primary infection with Mmm. We describe clinical and haematological outcomes, and dissect the humoral immune response over time, to specific antigens and compared the antibody responses between different pathomorphological outcomes. No antigen-specific antibodies correlating with protection were identified. Interestingly we found that animals that developed MycopIasma-containing sequestra had significantly higher antibody levels against proteins comprising the surface proteome than the animals that cleared Mycoplasma from their lungs. Based on these data we suggest that high antibody titres might play a role in the establishment of pathomorphological changes, such as vasculitis, which should be investigated in future studies. Beneficial antibody specificities and cellular immune responses need to be identified in order to foster the development of an improved vaccine in the future. (C) 2014 The Authors. Published by Elsevier B.V.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schieck, Elise UNSPECIFIED orcid.org/0000-0003-1756-6337 UNSPECIFIED Liljander, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamsten, Carl UNSPECIFIED UNSPECIFIED UNSPECIFIED Gicheru, Nimmo UNSPECIFIED UNSPECIFIED UNSPECIFIED Scacchia, Massimo UNSPECIFIED orcid.org/0000-0002-0013-9788 UNSPECIFIED Sacchini, Flavio UNSPECIFIED orcid.org/0000-0003-2618-6192 UNSPECIFIED Heller, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnee, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Sterner-Kock, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Hlinak, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Naessens, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Poole, Jane UNSPECIFIED UNSPECIFIED UNSPECIFIED Persson, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Jores, Joerg UNSPECIFIED orcid.org/0000-0003-3790-5746 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-432142
DOI:	10.1016/j.vetmic.2014.04.018
Journal or Publication Title:	Vet. Microbiol.
Volume:	172
Number:	1-2
Page Range:	S. 285 - 294
Date:	2014
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-2542
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CATTLE Multiple languages Microbiology; Veterinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43214