Universität zu Köln

Froelich, Jan, Banaschewski, Tobias ORCID: 0000-0003-4595-1144, Doepfner, Manfred and Goertz-Dorten, Anja (2014). An evaluation of the pharmacokinetics of methylphenidate for the treatment of attention-deficit/hyperactivity disorder. Expert Opin. Drug Metab. Toxicol., 10 (8). S. 1169 - 1184. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-7607

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Abstract

Introduction: Methylphenidate (MPH) plays a principal role in the multimodal treatment of attention-deficit/hyperactivity disorder (ADHD). Controlled studies have demonstrated an effective reduction in the core symptoms of the disorder following MPH therapy, although long-term studies also demonstrate that the therapeutic benefits dissipate in the absence of combined psychosocial interventions. Areas covered: This review article focuses on the pharmacological characteristics of MPH, examining its effects on brain metabolism and the neurotransmitter system. Neuropsychological and clinical effects of different immediate and extended release MPH formulations are discussed to aid clinicians in choosing the appropriate formulation. The drug's addictive potency and abuse potential is also discussed. Data came from a literature search of relevant studies performed using the PubMed database up to June 2013. Expert opinion: MPH is effective in the treatment of the core symptoms of ADHD. Considerable clinical expertise is required to identify an individually well-adapted dosage which will produce the optimal clinical effects with potential side effects minimized. Due to low adherence to medication, especially in adolescents, motivation to treatment and attentive clinical monitoring is mandatory, as is the consideration of risks of abuse or the presence of a comorbid addictive disorder.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Froelich, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Banaschewski, Tobias UNSPECIFIED orcid.org/0000-0003-4595-1144 UNSPECIFIED Doepfner, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Goertz-Dorten, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-432768
DOI:	10.1517/17425255.2014.922542
Journal or Publication Title:	Expert Opin. Drug Metab. Toxicol.
Volume:	10
Number:	8
Page Range:	S. 1169 - 1184
Date:	2014
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-7607
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEFICIT-HYPERACTIVITY DISORDER; EXTENDED-RELEASE DEXMETHYLPHENIDATE; STRIATAL DOPAMINE TRANSPORTER; CEREBRAL-BLOOD-FLOW; DOUBLE-BLIND; NOREPINEPHRINE TRANSPORTER; EXTRACELLULAR DOPAMINE; CLINICAL EFFECTIVENESS; THREO-METHYLPHENIDATE; STIMULANT MEDICATION Multiple languages Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43276