Universität zu Köln

Hofer, Annette and Wenz, Tina (2014). Post-translational modification of mitochondria as a novel mode of regulation. Exp. Gerontol., 56. S. 202 - 221. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-6815

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Abstract

Mitochondria not only form the metabolic hub, but also are crucial players in many cellular pathways, like apoptosis and innate immune response, putting the organelle in a central position in controlling cellular function and fate. As novel and powerful regulators of mitochondrial processes and hence mitochondrial-controlled pathways, post-translational modifications (PTMs) have emerged in the last years. In this review, we will summarize the current state of knowledge on PTMs occurring in mammalian mitochondria with a focus on phosphorylation, acetylation, succinylation and ubiquitination. We will highlight their regulatory role in metabolism, autophagy and apoptosis as well as communicating element to cellular stress response pathways such as the immune response. Finally, we will discuss open questions in this exciting research area and point out how mitochondrial PTMs might impact age-associated pathologies. (C) 2014 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hofer, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenz, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433281
DOI:	10.1016/j.exger.2014.03.006
Journal or Publication Title:	Exp. Gerontol.
Volume:	56
Page Range:	S. 202 - 221
Date:	2014
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-6815
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEPENDENT PROTEIN-KINASE; E3 UBIQUITIN LIGASE; TYROSINE-PHOSPHORYLATED PROTEINS; FATTY-ACID OXIDATION; COMPLEX-I; C-SRC; SKELETAL-MUSCLE; CELL-DEATH; SIRT3-MEDIATED DEACETYLATION; REVERSIBLE PHOSPHORYLATION Multiple languages Geriatrics & Gerontology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43328