Rovituso, Damiano, Heller, Stefanie, Schroeter, Michael, Kleinschnitz, Christoph ORCID: 0000-0002-1650-8875 and Kuerten, Stefanie (2014). B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients. J. Neuroimmunol., 272 (1-2). S. 86 - 91. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-8421
Full text not available from this repository.Abstract
In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-beta and natalizumab. Our data show that the frequency of the CD27(+)CD43(+) B1 cell subset was significantly diminished in RRMS patients compared to healthy subjects and that this subset was unaffected by treatment. Regardless of their true nature, we believe that these cells are part of the autoimmune disease pattern. (C) 2014 Elsevier B.V. All rights reserved.
Item Type: | Journal Article | ||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-433871 | ||||||||||||||||||||||||
DOI: | 10.1016/j.jneuroim.2014.04.008 | ||||||||||||||||||||||||
Journal or Publication Title: | J. Neuroimmunol. | ||||||||||||||||||||||||
Volume: | 272 | ||||||||||||||||||||||||
Number: | 1-2 | ||||||||||||||||||||||||
Page Range: | S. 86 - 91 | ||||||||||||||||||||||||
Date: | 2014 | ||||||||||||||||||||||||
Publisher: | ELSEVIER SCIENCE BV | ||||||||||||||||||||||||
Place of Publication: | AMSTERDAM | ||||||||||||||||||||||||
ISSN: | 1872-8421 | ||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/43387 |
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