Universität zu Köln

Glaesser, Christine, Haberer, Georg, Finkemeier, Iris ORCID: 0000-0002-8972-4026, Pfannschmidt, Thomas, Kleine, Tatjana, Leister, Dario ORCID: 0000-0003-1897-8421, Dietz, Karl-Josef ORCID: 0000-0003-0311-2182, Haeusler, Rainer Erich, Grimm, Bernhard and Mayer, Klaus Franz Xaver (2014). Meta-Analysis of Retrograde Signaling in Arabidopsis thaliana Reveals a Core Module of Genes Embedded in Complex Cellular Signaling Networks. Mol. Plant., 7 (7). S. 1167 - 1191. CAMBRIDGE: CELL PRESS. ISSN 1752-9867

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Abstract

Plastid-to-nucleus signaling is essential for the coordination and adjustment of cellular metabolism in response to environmental and developmental cues of plant cells. A variety of operational retrograde signaling pathways have been described that are thought to be triggered by reactive oxygen species, photosynthesis redox imbalance, tetrapyrrole intermediates, and other metabolic traits. Here we report a meta-analysis based on transcriptome and protein interaction data. Comparing the output of these pathways reveals the commonalities and peculiarities stimulated by six different sources impinging on operational retrograde signaling. Our study provides novel insights into the interplay of these pathways, supporting the existence of an as-yet unknown core response module of genes being regulated under all conditions tested. Our analysis further highlights affiliated regulatory cis-elements and classifies abscisic acid and auxin-based signaling as secondary components involved in the response cascades following a plastidial signal. Our study provides a global analysis of structure and interfaces of different pathways involved in plastid-to-nucleus signaling and a new view on this complex cellular communication network.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Glaesser, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Haberer, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Finkemeier, Iris UNSPECIFIED orcid.org/0000-0002-8972-4026 UNSPECIFIED Pfannschmidt, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleine, Tatjana UNSPECIFIED UNSPECIFIED UNSPECIFIED Leister, Dario UNSPECIFIED orcid.org/0000-0003-1897-8421 UNSPECIFIED Dietz, Karl-Josef UNSPECIFIED orcid.org/0000-0003-0311-2182 UNSPECIFIED Haeusler, Rainer Erich UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimm, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Mayer, Klaus Franz Xaver UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-434372
DOI:	10.1093/mp/ssu042
Journal or Publication Title:	Mol. Plant.
Volume:	7
Number:	7
Page Range:	S. 1167 - 1191
Date:	2014
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1752-9867
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MG-PROTOPORPHYRIN-IX; PHYTOCHROME-REGULATED TRANSCRIPTION; CYTOSOLIC CA2+ TRANSIENTS; PROTEIN PHOSPHATASE 2C; HORMONE ABSCISIC-ACID; AUXIN INFLUX CARRIERS; DNA-BINDING ACTIVITY; OXIDATIVE STRESS; REACTIVE OXYGEN; HIGH LIGHT Multiple languages Biochemistry & Molecular Biology; Plant Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43437