Universität zu Köln

Knapp, Juergen, Teschendorf, Peter, Scholz, Eberhard, Roewer, Joachim, Russ, Nicolai, Boettiger, Bernd W. and Popp, Erik (2014). Conductance Catheter Measurement and Effect of Different Anesthetics in a Rat Model of Postresuscitation Myocardial Dysfunction. J. Amer. Assoc. Lab. Anim. Sci., 53 (4). S. 392 - 399. MEMPHIS: AMER ASSOC LABORATORY ANIMAL SCIENCE. ISSN 1559-6109

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Abstract

We demonstrate the usefulness of left ventricular pressure-volume (PV) loops generated by the use of conductance catheter measurements and investigate the influence of the type of general anesthesia on postresuscitation myocardial dysfunction in a rat model of cardiac arrest (CA) and subsequent cardiopulmonary resuscitation. A total of 42 Wistar-Han rats were randomized to receive general anesthesia with sevoflurane and resuscitation after CA, general anesthesia with pentobarbital intraperitoneally and resuscitation after CA, or general anesthesia with pentobarbital without CA (sham group). Myocardial function, assessed by analysis of PV loops, was measured continuously and in real-time by using a PV-conductance catheter. Rats were monitored for 3 h after restoration of spontaneous circulation (ROSC). The use of PV-conductance catheters supported objective and reliable evaluation of myocardial function and proved feasible in this rat model of CA. End-diastolic volume increased in rats anesthetized with pentobarbital after ROSC (before CA, 237 +/- 45 mu A; after ROSC, 402 +/- 64 mu L). Preload-adjusted maximal power before CA was the same in all groups but decreased in both resuscitated groups. The decrease was less pronounced in rats anesthetized with sevoflurane compared with pentobarbital (11.8 +/- 4.9 mW/mu L-2 compared with 4.8 +/- 1.9 mW/mu L-2 at 3 h after ROSC). This finding indicates that the type of general anesthesia influences postresuscitation myocardial dysfunction in this rat model of experimentally induced CA and cardiopulmonary resuscitation. Rats that were anesthetized with sevoflurane exhibited less postresuscitation myocardial dysfunction than did those anesthetized with pentobarbital.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Knapp, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Teschendorf, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholz, Eberhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Roewer, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Russ, Nicolai UNSPECIFIED UNSPECIFIED UNSPECIFIED Boettiger, Bernd W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Popp, Erik UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-434571
Journal or Publication Title:	J. Amer. Assoc. Lab. Anim. Sci.
Volume:	53
Number:	4
Page Range:	S. 392 - 399
Date:	2014
Publisher:	AMER ASSOC LABORATORY ANIMAL SCIENCE
Place of Publication:	MEMPHIS
ISSN:	1559-6109
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HOSPITAL CARDIAC-ARREST; CARDIOPULMONARY-RESUSCITATION; VOLATILE ANESTHETICS; ATP-CHANNELS; IN-VIVO; SEVOFLURANE; ISOFLURANE; HEART; CONTRACTILITY; VOLUME Multiple languages Veterinary Sciences; Zoology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43457