Universität zu Köln

Schwarz, Emanuel, van Beveren, Nico J. M., Ramsey, Jordan, Leweke, F. Markus ORCID: 0000-0002-8163-195X, Rothermundt, Matthias, Bogerts, Bernhard, Steiner, Johann ORCID: 0000-0002-2611-2268, Guest, Paul C. and Bahn, Sabine (2014). Identification of Subgroups of Schizophrenia Patients With Changes in Either Immune or Growth Factor and Hormonal Pathways. Schizophr. Bull., 40 (4). S. 787 - 796. OXFORD: OXFORD UNIV PRESS. ISSN 1745-1701

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Abstract

Schizophrenia is a heterogeneous disorder normally diagnosed using the Diagnostic and Statistical Manual of Mental Disorders criteria. However, these criteria do not necessarily reflect differences in underlying molecular abnormalities of the disorder. Here, we have used multiplexed immunoassay analyses to measure immune molecules, growth factors, and hormones important to schizophrenia in acutely ill antipsychotic-naive patients (n = 180) and matched controls (n = 398). We found that using the resulting molecular profiles, we were capable of separating schizophrenia patients into 2 significantly distinct subgroups with predominant molecular abnormalities in either immune molecules or growth factors and hormones. These molecular profiles were tested using an independent cohort, and this showed the same separation into 2 subgroups. This suggests that distinct abnormalities occur in specific molecular pathways in schizophrenia patients. This may be of relevance for intervention studies that specifically target particular molecular mechanisms and could be a first step to further define the complex schizophrenia syndrome based on molecular profiles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schwarz, Emanuel UNSPECIFIED UNSPECIFIED UNSPECIFIED van Beveren, Nico J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramsey, Jordan UNSPECIFIED UNSPECIFIED UNSPECIFIED Leweke, F. Markus UNSPECIFIED orcid.org/0000-0002-8163-195X UNSPECIFIED Rothermundt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogerts, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Steiner, Johann UNSPECIFIED orcid.org/0000-0002-2611-2268 UNSPECIFIED Guest, Paul C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bahn, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-434755
DOI:	10.1093/schbul/sbt105
Journal or Publication Title:	Schizophr. Bull.
Volume:	40
Number:	4
Page Range:	S. 787 - 796
Date:	2014
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1745-1701
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; DECONSTRUCTING SCHIZOPHRENIA; OLIGODENDROCYTE VIABILITY; DOUBLE-BLIND; ERYTHROPOIETIN; SERUM; 1ST-EPISODE; MECHANISMS; CONVERGE Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43475