Mohty, M., Huebel, K., Kroeger, N., Aljurf, M., Apperley, J., Basak, G. W., Bazarbachi, A., Douglas, K., Gabriel, I., Garderet, L., Geraldes, C., Jaksic, O., Kattan, M. W., Koristek, Z., Lanza, F., Lemoli, R. M., Mendeleeva, L., Mikala, G., Mikhailova, N., Nagler, A., Schouten, H. C., Selleslag, D., Suciu, S., Sureda, A., Worel, N., Wuchter, P., Chabannon, C. and Duarte, R. F. (2014). Autologous haematopoietic stem cell mobilisation in multiple myeloma and lymphoma patients: a position statement from the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant., 49 (7). S. 865 - 873. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

Autologous haematopoietic SCT with PBSCs is regularly used to restore BM function in patients with multiple myeloma or lymphoma after myeloablative chemotherapy. Twenty-eight experts from the European Group for Blood and Marrow Transplantation developed a position statement on the best approaches to mobilising PBSCs and on possibilities of optimising graft yields in patients who mobilise poorly. Choosing the appropriate mobilisation regimen, based on patients' disease stage and condition, and optimising the apheresis protocol can improve mobilisation outcomes. Several factors may influence mobilisation outcomes, including older age, a more advanced disease stage, the type of prior chemotherapy (e.g., fludarabine or melphalan), prior irradiation or a higher number of prior treatment lines. The most robust predictive factor for poor PBSC collection is the CD34(+) cell count in PB before apheresis. Determination of the CD34(+) cell count in PB before apheresis helps to identify patients at risk of poor PBSC collection and allows pre-emptive intervention to rescue mobilisation in these patients. Such a proactive approach might help to overcome deficiencies in stem cell mobilisation and offers a rationale for the use of novel mobilisation agents.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mohty, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huebel, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroeger, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aljurf, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Apperley, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Basak, G. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bazarbachi, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Douglas, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gabriel, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garderet, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geraldes, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaksic, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kattan, M. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koristek, Z.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lanza, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lemoli, R. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mendeleeva, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mikala, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mikhailova, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nagler, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schouten, H. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Selleslag, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suciu, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sureda, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worel, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuchter, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chabannon, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duarte, R. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-435177
DOI: 10.1038/bmt.2014.39
Journal or Publication Title: Bone Marrow Transplant.
Volume: 49
Number: 7
Page Range: S. 865 - 873
Date: 2014
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-5365
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NON-HODGKINS-LYMPHOMA; PLUS G-CSF; HIGH-DOSE CHEMOTHERAPY; LARGE-VOLUME LEUKAPHERESIS; PROGRESSION-FREE SURVIVAL; COLONY-STIMULATING FACTOR; ADEQUATE PBSC COLLECTION; PERIPHERAL-BLOOD; LENALIDOMIDE THERAPY; GROWTH-FACTORMultiple languages
Biophysics; Oncology; Hematology; Immunology; TransplantationMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43517

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