Xu, Haifeng C., Grusdat, Melanie ORCID: 0000-0003-0708-0077, Pandyra, Aleksandra A., Polz, Robin, Huang, Jun, Sharma, Piyush ORCID: 0000-0003-1185-9534, Deenen, Rene, Koehrer, Karl, Rahbar, Ramtin, Diefenbach, Andreas ORCID: 0000-0002-9176-9530, Gibbert, Kathrin, Loehning, Max, Hoecker, Lena, Waibler, Zoe, Haeussinger, Dieter, Mak, Tak W., Ohashi, Pamela S. ORCID: 0000-0003-2915-9317, Lang, Karl S. and Lang, Philipp A. (2014). Type I Interferon Protects Antiviral CD8(+) T Cells from NK Cell Cytotoxicity. Immunity, 40 (6). S. 949 - 961. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

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Abstract

Despite development of new antiviral drugs, viral infections are still a major health problem. The most potent antiviral defense mechanism is the innate production of type I interferon (IFN-I), which not only limits virus replication but also promotes antiviral T cell immunity through mechanisms, which remain insufficiently studied. Using the murine lymphocytic choriomeningitis virus model system, we show here that IFN-I signaling on T cells prevented their rapid elimination in vivo. Microarray analyses uncovered that IFN-I triggered the expression of selected inhibitory NK-cell-receptor ligands. Consequently, T cell immunity of IFN-I receptor (IFNAR)-deficient T cells could be restored by NK cell depletion or in NK-cell-deficient hosts (Nfil3(-/-)).The elimination of Ifnar1(-/-) T cells was dependent on NK-cell-mediated perforin expression. In summary, we identified IFN-I as a key player regulating the protection of T cells against regulatory NK cell function.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Xu, Haifeng C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grusdat, MelanieUNSPECIFIEDorcid.org/0000-0003-0708-0077UNSPECIFIED
Pandyra, Aleksandra A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polz, RobinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, JunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sharma, PiyushUNSPECIFIEDorcid.org/0000-0003-1185-9534UNSPECIFIED
Deenen, ReneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehrer, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahbar, RamtinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diefenbach, AndreasUNSPECIFIEDorcid.org/0000-0002-9176-9530UNSPECIFIED
Gibbert, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loehning, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoecker, LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waibler, ZoeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haeussinger, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mak, Tak W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ohashi, Pamela S.UNSPECIFIEDorcid.org/0000-0003-2915-9317UNSPECIFIED
Lang, Karl S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, Philipp A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-435686
DOI: 10.1016/j.immuni.2014.05.004
Journal or Publication Title: Immunity
Volume: 40
Number: 6
Page Range: S. 949 - 961
Date: 2014
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1097-4180
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NATURAL-KILLER-CELLS; PLASMACYTOID DENDRITIC CELLS; CHRONIC HEPATITIS-C; IMMUNE-RESPONSES; TRANSGENIC MICE; RECEPTOR; VIRUS; EFFECTOR; THERAPY; INNATEMultiple languages
ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43568

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