Universität zu Köln

Kloth, Michael and Buettner, Reinhard (2014). Changing Histopathological Diagnostics by Genome-Based Tumor Classification. Genes, 5 (2). S. 444 - 460. BASEL: MDPI. ISSN 2073-4425

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Abstract

Traditionally, tumors are classified by histopathological criteria, i.e., based on their specific morphological appearances. Consequently, current therapeutic decisions in oncology are strongly influenced by histology rather than underlying molecular or genomic aberrations. The increase of information on molecular changes however, enabled by the Human Genome Project and the International Cancer Genome Consortium as well as the manifold advances in molecular biology and high-throughput sequencing techniques, inaugurated the integration of genomic information into disease classification. Furthermore, in some cases it became evident that former classifications needed major revision and adaption. Such adaptations are often required by understanding the pathogenesis of a disease from a specific molecular alteration, using this molecular driver for targeted and highly effective therapies. Altogether, reclassifications should lead to higher information content of the underlying diagnoses, reflecting their molecular pathogenesis and resulting in optimized and individual therapeutic decisions. The objective of this article is to summarize some particularly important examples of genome-based classification approaches and associated therapeutic concepts. In addition to reviewing disease specific markers, we focus on potentially therapeutic or predictive markers and the relevance of molecular diagnostics in disease monitoring.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kloth, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-436085
DOI:	10.3390/genes5020444
Journal or Publication Title:	Genes
Volume:	5
Number:	2
Page Range:	S. 444 - 460
Date:	2014
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2073-4425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC MYELOID-LEUKEMIA; WORLD-HEALTH-ORGANIZATION; GROWTH-FACTOR RECEPTOR; TRANSCRIPTION FACTOR; POLYCYTHEMIA-VERA; IMPROVED SURVIVAL; TYROSINE KINASE; CANCER; MUTATIONS; JAK2 Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43608