Universität zu Köln

Huang, Jia, Yu, Xiaojie, Fries, Jochen W. U., Zhang, Li'ang and Odenthal, Margarete (2014). MicroRNA Function in the Profibrogenic Interplay upon Chronic Liver Disease. Int. J. Mol. Sci., 15 (6). S. 9360 - 9372. BASEL: MDPI. ISSN 1422-0067

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Abstract

In chronic liver disease leading to fibrosis, hepatic stellate cells (HSC) differentiate into myofibroblasts. Myofibroblastic HSC have taken center stage during liver fibrogenesis, due to their remarkable synthesis of extracellular matrix proteins, their secretion of profibrogenic mediators and their contribution to hypertension, due to elevated contractility. MicroRNAs (miRNAs) are small, noncoding RNA molecules of 19-24 nucleotides in length. By either RNA interference or inhibition of translational initiation and elongation, each miRNA is able to inhibit the gene expression of a wide panel of targeted transcripts. Recently, it was shown that altered miRNA patterns after chronic liver disease highly affect the progression of fibrosis by their potential to target the expression of extracellular matrix proteins and the synthesis of mediators of profibrogenic pathways. Here, we underline the role of miRNAs in the interplay of the profibrogenic cell communication pathways upon myofibroblastic differentiation of hepatic stellate cells in the chronically injured liver.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Huang, Jia UNSPECIFIED UNSPECIFIED UNSPECIFIED Yu, Xiaojie UNSPECIFIED UNSPECIFIED UNSPECIFIED Fries, Jochen W. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Li'ang UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, Margarete UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-436476
DOI:	10.3390/ijms15069360
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	15
Number:	6
Page Range:	S. 9360 - 9372
Date:	2014
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPATIC STELLATE CELLS; NONALCOHOLIC STEATOHEPATITIS; CANCER-DIAGNOSIS; GROWTH-FACTOR; EXPRESSION; MIR-29; ACTIVATION; MECHANISMS; INFECTION; FIBROSIS Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43647