Universität zu Köln

Worm, Margitta ORCID: 0000-0002-3449-1245, Eckermann, Oliver, Doelle, Sabine, Aberer, Werner, Beyer, Kirsten, Hawranek, Thomas, Hompes, Stephanie, Koehli, Alice, Mahler, Vera, Nemat, Katja, Niggemann, Bodo, Pfoehler, Claudia, Rabe, Uta, Reissig, Angelika, Rietschel, Ernst, Scherer, Kathrin, Treudler, Regina and Rueff, Franziska (2014). Triggers and Treatment of Anaphylaxis An Analysis of 4000 Cases From Germany, Austria and Switzerland. Dtsch. Arztebl. Int., 111 (21). S. 367 - 378. COLOGNE: DEUTSCHER AERZTE-VERLAG GMBH. ISSN 1866-0452

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Abstract

Background: Anaphylaxis is the most severe manifestation of a mast cell-dependent immediate reaction and may be fatal. According to data from the Berlin region, its incidence is 2-3 cases per 100 000 persons per year. Methods: We evaluated data from the anaphylaxis registry of the German-speaking countries for 2006-2013 and data from the protocols of the ADAC air rescue service for 2010-2011 to study the triggers, clinical manifestations, and treatment of anaphylaxis. Results: The registry contained data on 4141 patients, and the ADAC air rescue protocols concerned 1123 patients. In the registry, the most common triggers for anaphylaxis were insect venom (n = 2074; 50.1%), foods (n = 1039; 25.1%), and drugs (n = 627; 15.1%). Within these groups, the most common triggers were wasp (n = 1460) and bee stings (n = 412), legumes (n = 241), animal proteins (n = 225), and analgesic drugs (n = 277). Food anaphylaxis was most frequently induced by peanuts, cow milk, and hen's egg in children and by wheat and shellfish in adults. An analysis of the medical emergency cases revealed that epinephrine was given for grade 3 or 4 anaphylaxis to 14.5% and 43.9% (respectively) of the patients in the anaphylaxis registry and to 19% and 78% of the patients in the air rescue protocols. Conclusion: Wasp and bee venom, legumes, animal proteins, and analgesic drugs were the commonest triggers of anaphylaxis. Their relative frequency was age-dependent. Epinephrine was given too rarely, as it is recommended in the guidelines for all cases of grade 2 and above.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Worm, Margitta UNSPECIFIED orcid.org/0000-0002-3449-1245 UNSPECIFIED Eckermann, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Doelle, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Aberer, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyer, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Hawranek, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hompes, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehli, Alice UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahler, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Nemat, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Niggemann, Bodo UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfoehler, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rabe, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Reissig, Angelika UNSPECIFIED UNSPECIFIED UNSPECIFIED Rietschel, Ernst UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherer, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Treudler, Regina UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueff, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437744
DOI:	10.3238/arztebl.2014.0367
Journal or Publication Title:	Dtsch. Arztebl. Int.
Volume:	111
Number:	21
Page Range:	S. 367 - 378
Date:	2014
Publisher:	DEUTSCHER AERZTE-VERLAG GMBH
Place of Publication:	COLOGNE
ISSN:	1866-0452
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WORLD-ALLERGY-ORGANIZATION; FOOD; EPIDEMIOLOGY; TRENDS Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43774