Universität zu Köln

Wille, Sebastian, Schumacher, Pauline, Paas, Jenny, Tenholte, Dirk, Eminaga, Okyaz, Mueller, Ute, Muthen, Noemi, Mehner, Jan, Cornely, Oliver and Engelmann, Udo (2014). Catheterless Long-Term Ambulatory Urodynamic Measurement Using a Novel Three-Device System. PLoS One, 9 (5). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Aims: Long-term urodynamics are required because bladder-emptying disorders are often not clearly revealed by conventional urodynamics. Patients with severe clinical overactive bladder symptoms, for instance, often show normal results. This may be due to the short evaluation time and psychological factors that complicate conventional urodynamics. This study aimed to develop an ambulatory three-component urodynamic measurement system that is easy to operate, registers urodynamic parameters for several days, and has no negative impact on the patient. Methods: We developed an intravesical capsule combined with a hand-held device to register voiding desire and micturition, and an alarm pad device that detects urine loss. Recently, the intravesical capsule and its proven function were detailed in the literature. Here, we present detailed in vitro results using a female bladder model. The flexible capsule was C-shaped to minimize the risk of expulsion from the bladder during micturition. Results of biocompatibility evaluation of the intravesical capsule, which is called Wille Capsule (WiCa) are described. Results: The WiCa with an oval nose and a maximum outer diameter of 5.5 mm was easily inserted through a 25-French cystoscope. Removing the WiCa by grasping the nose using the female model with bladder was easily conducted. Expulsion of the WiCa during voiding was avoided through a novel C-shaped device design. Based on in vitro cytotoxicity studies, the capsule is a promising and safe device. Conclusion: Our novel system is an innovative minimally-invasive tool for accurate long-term urodynamic measurement, and does not require inserting a transurethral catheter.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wille, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Pauline UNSPECIFIED UNSPECIFIED UNSPECIFIED Paas, Jenny UNSPECIFIED UNSPECIFIED UNSPECIFIED Tenholte, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Eminaga, Okyaz UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Muthen, Noemi UNSPECIFIED UNSPECIFIED UNSPECIFIED Mehner, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Engelmann, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-438204
DOI:	10.1371/journal.pone.0096280
Journal or Publication Title:	PLoS One
Volume:	9
Number:	5
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DETRUSOR OVERACTIVITY; BLADDER; PRESSURE; BIOCOMPATIBILITY; SYMPTOMS Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43820