Universität zu Köln

Klose, G., Beil, F. U., Dieplinger, H., von Eckardstein, A., Foeger, B., Gouni-Berthold, I., Koenig, W., Kostner, G. M., Landmesser, U., Laufs, U., Leistikow, F., Maerz, W., Merkel, M., Mueller-Wieland, D., Noll, G., Parhofer, K. G., Paulweber, B., Riesen, W., Schaefer, J. R., Steinhagen-Thiessen, E., Steinmetz, A., Toplak, H., Wanner, C. and Windler, E. (2014). New AHA and ACC guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk. Statement of the D center dot A center dot CH Society for Prevention of Cardiovascular Diseases, the Austrian Atherosclerosis Society and the Working Group on Lipids and Atherosclerosis (AGLA) of the Swiss Society for Cardiology. Internist, 55 (5). S. 601 - 607. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1289

Full text not available from this repository.

Abstract

Guidelines for the reduction of cholesterol to prevent atherosclerotic vascular events were recently released by the American Heart Association and the American College of Cardiology. The authors claim to refer entirely to evidence from randomized controlled trials, thereby confining their guidelines to statins as the primary therapeutic option. The guidelines derived from these trials do not specify treatment goals, but refer to the percentage of cholesterol reduction by statin medication with low, moderate, and high intensity. However, these targets are just as little tested in randomized trials as are the cholesterol goals derived from clinical experience. The same applies to the guidelines of the four patient groups which are defined by vascular risk. No major statin trial has included patients on the basis of their global risk; thus the allocation criteria are also arbitrarily chosen. These would actually lead to a significant increase in the number of patients to be treated with high or maximum dosages of statins. Also, adhering to dosage regulations instead of cholesterol goals contradicts the principles of individualized patient care. The option of the new risk score to calculate lifetime risk up to the age of 80 years in addition to the 10-year risk can be appreciated. Unfortunately it is not considered in the therapeutic recommendations provided, despite evidence from population and genetic studies showing that even a moderate lifetime reduction of low-density lipoprotein (LDL) cholesterol or non-HDL cholesterol has a much stronger effect than an aggressive treatment at an advanced age. In respect to secondary prevention, the new American guidelines broadly match the European guidelines. Thus, the involved societies from Germany, Austria and Switzerland recommend continuing according to established standards, such as the EAS/ESC guidelines.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klose, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beil, F. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dieplinger, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Eckardstein, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foeger, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gouni-Berthold, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kostner, G. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Landmesser, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laufs, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leistikow, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maerz, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller-Wieland, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Noll, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Parhofer, K. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paulweber, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riesen, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinhagen-Thiessen, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinmetz, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Toplak, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wanner, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Windler, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439138
DOI:	10.1007/s00108-014-3492-z
Journal or Publication Title:	Internist
Volume:	55
Number:	5
Page Range:	S. 601 - 607
Date:	2014
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1289
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORONARY-HEART-DISEASE; CONTROLLED-TRIAL; ATORVASTATIN; SIMVASTATIN; PREDICTION Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43913