Universität zu Köln

Baues, C. M., Semrau, R., Nast-Kolb, B. and Eich, H. T. (2014). Role of radiotherapy in Hodgkin's lymphoma. Onkologe, 20 (5). S. 441 - 447. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

Radiotherapy is a well-established element in the treatment of Hodgkin's lymphoma. An analysis of the literature in the database PubMed on the development and importance of radiotherapy within the framework of treatment of Hodgkin's lymphoma was performed. Over the last century radiotherapy has been shown to be the most effective single modality in the treatment of Hodgkin's lymphoma. In the beginning extended field radiotherapy (EF-RT) was commonly used and induced remission rates of 90 % in early stage Hodgkin's lymphoma. However, further improvement of freedom from treatment failure (FFTF) could only be achieved through the addition of polychemotherapy. This multimodal treatment concept has been rigorously tested over many generations in clinical trials leading to continuous reduction in the radiation dose and target volume with the same or better efficiency. More recent studies focused on reducing therapy-associated side effects especially in young patients who have an excellent long-term prognosis, by attempting to stratify treatment with possible reduction in therapy intensity. In the era of personalized medicine, treatment regimes will focus on targeted systemic therapy but will still rely on highly effective consolidating radiotherapy (combined modality).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baues, C. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Semrau, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nast-Kolb, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eich, H. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439193
DOI:	10.1007/s00761-013-2635-5
Journal or Publication Title:	Onkologe
Volume:	20
Number:	5
Page Range:	S. 441 - 447
Date:	2014
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVOLVED-FIELD RADIOTHERAPY; NODE RADIOTHERAPY; FINAL ANALYSIS; CHEMOTHERAPY; PREDOMINANT; DISEASE; TRIAL; INTENSITY; RADIATION; RITUXIMAB Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43919