Universität zu Köln

Behringer, K., Halbsguth, T. V. and Borchmann, P. (2014). Late sequelae and survivorship following treatment of Hodgkin's lymphoma. Onkologe, 20 (5). S. 470 - 477. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

As a consequence of the impressive long-term remission rates in Hodgkin's lymphoma (HL) patients, current clinical research focuses on the reduction of treatment-related delayed complications. Thus, carefully conducted analyses of treatment-related sequelae which can occur during the survivorship period are needed. The most important treatment-related complication is the development of secondary neoplasms, which represent a significant risk of mortality in long-term HL survivors. Organ toxicities comprise cardiac, pulmonary and gonadal dysfunction, of which the latter is particularly important in young survivors with a desire to have children. At diagnosis, physicians should thoroughly inform the patient and consider protective methods to preserve fertility. Furthermore, the quality of life in HL survivors is lower than in controls of the same age. Most survivors suffer from cancer-related fatigue, which can persist a long time after primary treatment. The therapeutic strategies of most recent clinical trials in HL aim at reducing therapy-related late sequelae with a simultaneous retention of good tumor control.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behringer, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Halbsguth, T. V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439237
DOI:	10.1007/s00761-013-2638-2
Journal or Publication Title:	Onkologe
Volume:	20
Number:	5
Page Range:	S. 470 - 477
Date:	2014
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM SURVIVORS; BREAST-CANCER; GONADAL-FUNCTION; 2ND MALIGNANCY; MYELOID-LEUKEMIA; FEMALE SURVIVORS; OVARIAN TISSUE; YOUNG-WOMEN; DISEASE; FERTILITY Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43923