Universität zu Köln

Hinkelammert, Reemt, Eminaga, Okyaz, Bettendorf, Olaf, Eltze, Elke, Abbas, Mahmoud, Hertle, Lothar and Semjonow, Axel (2014). Tumor percentage but not number of tumor foci predicts disease-free survival after radical prostatectomy especially in high-risk patients. Urol. Oncol.-Semin. Orig. Investig., 32 (4). S. 403 - 413. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-2496

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Abstract

Objective: To evaluate the predictive value of tumor volume (TV), tumor percentage (TP), and number of tumor foci (NF) in patients with prostate cancer. The prognostic relevance of TV, TP, and NF as predictors of biochemical recurrence (BCR) following radical prostatectomy (RPE) is controversial. Patients and methods: The cohort consisted of 758 referred subjects who underwent RPE between 2000 and 2005 at the University of Muenster. The mean time of follow-up was 62 months. TV, TP, and NF were estimated visually with the assistance of a pathologic mapping grid for embedded whole-mount RPE specimens. In addition, TV and TP were assessed in a categorized fashion by using quartiles as cutoff points. Subgroup analyses for high- and low-risk patients using univariate and multivariate Cox proportional hazard analyses for BCR were performed. Results: TV, TP, and NF were strongly related to tumor stage, Gleason score, surgical margin status, and preoperative prostate-specific antigen (PSA). In univariate analysis, all pathologic parameters including TV, TP, and NF were predictive for BCR. In multivariate analysis, only TP, tumor stage, and PSA level were independent predictors. In subgroup analysis, TP was an independent predictor for BCR in the high-risk group but not in the low-risk group. Conclusions: TP, but not TV or NF, was found to be an independent predictor for BCR in patients after RPE, TP seems to be more relevant in high-risk patients (i.e., any of the following: >pT2, Gleason score >6, or PSA >20 ng/ml). (C) 2014 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hinkelammert, Reemt UNSPECIFIED UNSPECIFIED UNSPECIFIED Eminaga, Okyaz UNSPECIFIED UNSPECIFIED UNSPECIFIED Bettendorf, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Eltze, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Abbas, Mahmoud UNSPECIFIED UNSPECIFIED UNSPECIFIED Hertle, Lothar UNSPECIFIED UNSPECIFIED UNSPECIFIED Semjonow, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439426
DOI:	10.1016/j.urolonc.2013.10.001
Journal or Publication Title:	Urol. Oncol.-Semin. Orig. Investig.
Volume:	32
Number:	4
Page Range:	S. 403 - 413
Date:	2014
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-2496
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDEPENDENT PREDICTOR; VISUAL ESTIMATION; RECURRENCE; CANCER; VOLUME; CARCINOMA; ADENOCARCINOMA; HETEROGENEITY; SPECIMEN; FOCALITY Multiple languages Oncology; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43942