Universität zu Köln

Adamchic, Ilya, Toth, Timea, Hauptmann, Christian and Tass, Peter Alexander (2014). Reversing pathologically increased EEG power by acoustic coordinated reset neuromodulation. Hum. Brain Mapp., 35 (5). S. 2099 - 2119. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Acoustic Coordinated Reset (CR) neuromodulation is a patterned stimulation with tones adjusted to the patient's dominant tinnitus frequency, which aims at desynchronizing pathological neuronal synchronization. In a recent proof-of-concept study, CR therapy, delivered 4-6 h/day more than 12 weeks, induced a significant clinical improvement along with a significant long-lasting decrease of pathological oscillatory power in the low frequency as well as gamma band and an increase of the alpha power in a network of tinnitus-related brain areas. As yet, it remains unclear whether CR shifts the brain activity toward physiological levels or whether it induces clinically beneficial, but nonetheless abnormal electroencephalographic (EEG) patterns, for example excessively decreased delta and/or gamma. Here, we compared the patients' spontaneous EEG data at baseline as well as after 12 weeks of CR therapy with the spontaneous EEG of healthy controls by means of Brain Electrical Source Analysis source montage and standardized low-resolution brain electromagnetic tomography techniques. The relationship between changes in EEG power and clinical scores was investigated using a partial least squares approach. In this way, we show that acoustic CR neuromodulation leads to a normalization of the oscillatory power in the tinnitus-related network of brain areas, most prominently in temporal regions. A positive association was found between the changes in tinnitus severity and the normalization of delta and gamma power in the temporal, parietal, and cingulate cortical regions. Our findings demonstrate a widespread CR-induced normalization of EEG power, significantly associated with a reduction of tinnitus severity. Hum Brain Mapp 35:2099-2118, 2014. (c) 2013 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Adamchic, Ilya UNSPECIFIED UNSPECIFIED UNSPECIFIED Toth, Timea UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauptmann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Tass, Peter Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439651
DOI:	10.1002/hbm.22314
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	35
Number:	5
Page Range:	S. 2099 - 2119
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; HUMAN AUDITORY-CORTEX; TINNITUS INTENSITY; NEURAL ACTIVITY; ALPHA; NEUROFEEDBACK; GENERATION; NEURONS; MODEL; THETA Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43965