Universität zu Köln

Rivolta, Davide ORCID: 0000-0002-9969-9135, Castellanos, Nazareth P., Stawowsky, Cerisa, Helbling, Saskia, Wibral, Michael ORCID: 0000-0001-8010-5862, Gruetzner, Christine, Koethe, Dagmar, Birkner, Katharina, Kranaster, Laura, Enning, Frank, Singer, Wolf, Leweke, F. Markus ORCID: 0000-0002-8163-195X and Uhlhaas, Peter J. (2014). Source-Reconstruction of Event-Related Fields Reveals Hyperfunction and Hypofunction of Cortical Circuits in Antipsychotic-Naive, First-Episode Schizophrenia Patients during Mooney Face Processing. J. Neurosci., 34 (17). S. 5909 - 5918. WASHINGTON: SOC NEUROSCIENCE. ISSN 1529-2401

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Abstract

Schizophrenia is characterized by dysfunctions in neural circuits that can be investigated with electrophysiological methods, such as EEG and MEG. In the present human study, we examined event-related fields (ERFs), in a sample of medication-naive, first-episode schizophrenia (FE-ScZ) patients (n = 14) and healthy control participants (n = 17) during perception of Mooney faces to investigate the integrity of neuromagnetic responses and their experience-dependent modification. ERF responses were analyzed for M100, M170, and M250 components at the sensor and source levels. In addition, we analyzed peak latency and adaptation effects due to stimulus repetition. FE-ScZ patients were characterized by significantly impaired sensory processing, as indicated by a reduced discrimination index (A'). At the sensor level, M100 and M170 responses in FE-ScZ were within the normal range, whereas the M250 response was impaired. However, source localization revealed widespread elevated activity for M100 and M170 in FE-ScZ and delayed peak latencies for the M100 and M250 responses. In addition, M170 source activity in FE-ScZ was not modulated by stimulus repetitions. The present findings suggest that neural circuits in FE-ScZ may be characterized by a disturbed balance between excitation and inhibition that could lead to a failure to gate information flow and abnormal spreading of activity, which is compatible with dysfunctional glutamatergic neurotransmission.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rivolta, Davide UNSPECIFIED orcid.org/0000-0002-9969-9135 UNSPECIFIED Castellanos, Nazareth P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stawowsky, Cerisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Helbling, Saskia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wibral, Michael UNSPECIFIED orcid.org/0000-0001-8010-5862 UNSPECIFIED Gruetzner, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Koethe, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Birkner, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kranaster, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Enning, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Singer, Wolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Leweke, F. Markus UNSPECIFIED orcid.org/0000-0002-8163-195X UNSPECIFIED Uhlhaas, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-440457
DOI:	10.1523/JNEUROSCI.3752-13.2014
Journal or Publication Title:	J. Neurosci.
Volume:	34
Number:	17
Page Range:	S. 5909 - 5918
Date:	2014
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	1529-2401
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OBJECT RECOGNITION; PERMUTATION TESTS; NEURAL RESPONSE; KETAMINE; DEFICITS; DYSFUNCTION; PERCEPTION; DYNAMICS; INFORMATION; VALIDATION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44045