Universität zu Köln

Schilbach, Leonhard ORCID: 0000-0001-5547-8309, Mueller, Veronika I., Hoffstaedter, Felix ORCID: 0000-0001-7163-3110, Clos, Mareike ORCID: 0000-0002-1611-9474, Goya-Maldonado, Roberto, Gruber, Oliver and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2014). Meta-Analytically Informed Network Analysis of Resting State fMRI Reveals Hyperconnectivity in an Introspective Socio-Affective Network in Depression. PLoS One, 9 (4). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Alterations of social cognition and dysfunctional interpersonal expectations are thought to play an important role in the etiology of depression and have, thus, become a key target of psychotherapeutic interventions. The underlying neurobiology, however, remains elusive. Based upon the idea of a close link between affective and introspective processes relevant for social interactions and alterations thereof in states of depression, we used a meta-analytically informed network analysis to investigate resting-state functional connectivity in an introspective socio-affective (ISA) network in individuals with and without depression. Results of our analysis demonstrate significant differences between the groups with depressed individuals showing hyperconnectivity of the ISA network. These findings demonstrate that neurofunctional alterations exist in individuals with depression in a neural network relevant for introspection and socio-affective processing, which may contribute to the interpersonal difficulties that are linked to depressive symptomatology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Mueller, Veronika I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffstaedter, Felix UNSPECIFIED orcid.org/0000-0001-7163-3110 UNSPECIFIED Clos, Mareike UNSPECIFIED orcid.org/0000-0002-1611-9474 UNSPECIFIED Goya-Maldonado, Roberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruber, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-440472
DOI:	10.1371/journal.pone.0094973
Journal or Publication Title:	PLoS One
Volume:	9
Number:	4
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TREATMENT-RESISTANT DEPRESSION; DEEP BRAIN-STIMULATION; FUNCTIONAL CONNECTIVITY; DISORDER; AMYGDALA Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44047