Universität zu Köln

Li, K. -W., Kim, D-S., Zaucke, F. and Luo, Z. D. (2014). Trigeminal nerve injury-induced thrombospondin-4 up-regulation contributes to orofacial neuropathic pain states in a rat model. Eur. J. Pain, 18 (4). S. 489 - 496. HOBOKEN: WILEY-BLACKWELL. ISSN 1532-2149

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Abstract

BackgroundInjury to the trigeminal nerve often results in the development of chronic pain states including tactile allodynia, or hypersensitivity to light touch, in orofacial area, but its underlying mechanisms are poorly understood. Peripheral nerve injury has been shown to cause up-regulation of thrombospondin-4 (TSP4) in dorsal spinal cord that correlates with neuropathic pain development. In this study, we examined whether injury-induced TSP4 is critical in mediating orofacial pain development in a rat model of chronic constriction injury to the infraorbital nerve. MethodsOrofacial sensitivity to mechanical stimulation was examined in a unilateral infraorbital nerve ligation rat model. The levels of TSP4 in trigeminal ganglia and associated spinal subnucleus caudalis and C1/C2 spinal cord (Vc/C2) from injured rats were examined at time points correlating with the initiation and peak orofacial hypersensitivity. TSP4 antisense and mismatch oligodeoxynucleotides were intrathecally injected into injured rats to see if antisense oligodeoxynucleotide treatment could reverse injury-induced TSP4 up-regulation and orofacial behavioural hypersensitivity. ResultsOur data indicated that trigeminal nerve injury induced TSP4 up-regulation in Vc/C2 at a time point correlated with orofacial tactile allodynia. In addition, intrathecal treatment with TSP4 antisense, but not mismatch, oligodeoxynucleotides blocked both injury-induced TSP4 up-regulation in Vc/C2 and behavioural hypersensitivity. ConclusionsOur data support that infraorbital nerve injury leads to TSP4 up-regulation in trigeminal spinal complex that contributes to orofacial neuropathic pain states. Blocking this pathway may provide an alternative approach in management of orofacial neuropathic pain states.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, K. -W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, D-S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaucke, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Luo, Z. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-441141
DOI:	10.1002/j.1532-2149.2013.00396.x
Journal or Publication Title:	Eur. J. Pain
Volume:	18
Number:	4
Page Range:	S. 489 - 496
Date:	2014
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1532-2149
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEDULLARY DORSAL-HORN; CHRONIC CONSTRICTION INJURY; QUALITY-OF-LIFE; CENTRAL SENSITIZATION; NOCICEPTIVE NEURONS; SUBNUCLEUS CAUDALIS; INFRAORBITAL NERVE; SEX; MECHANISMS; BEHAVIOR Multiple languages Anesthesiology; Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44114