Universität zu Köln

Heidlindemann, Marcel, Rulli, Giuseppe, Berkessel, Albrecht ORCID: 0000-0003-0470-7428, Hummel, Werner and Groeger, Harald (2014). Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments. ACS Catal., 4 (4). S. 1099 - 1104. WASHINGTON: AMER CHEMICAL SOC. ISSN 2155-5435

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Abstract

A proof of concept for the combination of an asymmetric organocatalytic reaction with a biotransformation toward a one-pot like process for 1,3-diols based on immobilized organo- and biocatalysts, which are utilized in different compartments, is demonstrated. This process which runs completely in organic media consists of an initial proline-derivative-catalyzed aldol reaction and a subsequent reduction of the aldol adduct catalyzed by an alcohol dehydrogenase (ADH) without the need for intermediate isolation. Economically attractive superabsorber-based coimmobilization for the ADH and its cofactor NAD(+) turned out to give a highly efficient biocatalyst with excellent reusability and simple product separation from the immobilizate under avoidance of any tedious extraction steps during the overall process.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heidlindemann, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Rulli, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Berkessel, Albrecht UNSPECIFIED orcid.org/0000-0003-0470-7428 UNSPECIFIED Hummel, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Groeger, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-441962
DOI:	10.1021/cs4010387
Journal or Publication Title:	ACS Catal.
Volume:	4
Number:	4
Page Range:	S. 1099 - 1104
Date:	2014
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	2155-5435
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIRECT ALDOL REACTION; ONE-POT; ENZYME; REDUCTION; 1,3-DIOLS Multiple languages Chemistry, Physical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/44196