Universität zu Köln

Schaefer, Gritt, Narasimha, Maithreyi, Vogelsang, Elisabeth and Leptin, Maria ORCID: 0000-0001-7097-348X (2014). Cadherin switching during the formation and differentiation of the Drosophila mesoderm - implications for epithelial-to-mesenchymal transitions. J. Cell Sci., 127 (7). S. 1511 - 1523. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 1477-9137

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Abstract

Epithelial-to-mesenchymal transition (EMT) is typically accompanied by downregulation of epithelial (E-) cadherin, and is often additionally accompanied by upregulation of a mesenchymal or neuronal (N-) cadherin. Snail represses transcription of the E-cadherin gene both during normal development and during tumour spreading. The formation of the mesodermal germ layer in Drosophila, considered a paradigm of a developmental EMT, is associated with Snailmediated repression of E-cadherin and the upregulation of Ncadherin. By using genetic manipulation to remove or overexpress the cadherins, we show here that the complementarity of cadherin expression is not necessary for the segregation or the dispersal of the mesodermal germ layer in Drosophila. However, we discover different effects of E- and N- cadherin on the differentiation of subsets of mesodermal derivatives, which depend on Wingless signalling from the ectoderm, indicating differing abilities of E- and N-cadherin to bind to and sequester the common junctional and signalling effector beta-catenin. These results suggest that the downregulation of E-cadherin in the mesoderm might be required to facilitate optimal levels of Wingless signalling.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schaefer, Gritt UNSPECIFIED UNSPECIFIED UNSPECIFIED Narasimha, Maithreyi UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogelsang, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Leptin, Maria UNSPECIFIED orcid.org/0000-0001-7097-348X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-442556
DOI:	10.1242/jcs.139485
Journal or Publication Title:	J. Cell Sci.
Volume:	127
Number:	7
Page Range:	S. 1511 - 1523
Date:	2014
Publisher:	COMPANY OF BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9137
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-CELL ADHESION; TRANSCRIPTION FACTOR SNAIL; ALPHA-CATENIN; N-CADHERIN; ADHERENS JUNCTIONS; DE-CADHERIN; CAENORHABDITIS-ELEGANS; BETA-CATENIN; SHAPE CHANGE; DN-CADHERIN Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/44255