Universität zu Köln

Filss, Christian P., Galldiks, Norbert ORCID: 0000-0002-2485-1796, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Sabel, Michael, Wittsack, Hans J., Turowski, Bernd, Antoch, Gerald, Zhang, Ke, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Coenen, Heinz H., Shah, Nadim J., Herzog, Hans and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2014). Comparison of F-18-FET PET and Perfusion-Weighted MR Imaging: A PET/MR Imaging Hybrid Study in Patients with Brain Tumors. J. Nucl. Med., 55 (4). S. 540 - 546. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

PET using O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) provides important diagnostic information in addition to that from conventional MR imaging on tumor extent and activity of cerebral gliomas. Recent studies suggest that perfusion-weighted MR imaging (PWI), especially maps of regional cerebral blood volume (rCBV), may provide similar diagnostic information. In this study, we directly compared F-18-FET PET and PWI in patients with brain tumors. Methods: Fifty-six patients with gliomas were investigated using static F-18-FET PET and PWI. For comparison, 8 patients with meningiomas were included. We generated a set of tumor and reference volumes of interest (VOIs) based on morphologic MR imaging and transferred these VOIs to the corresponding F-18-FET PET scans and PWI maps. From these VOIs, tumor-to-brain ratios (TBR) were calculated, and normalized histograms were generated for F-18-FET PET and rCBV maps. Furthermore, in rCBV maps and in F-18-FET PET scans, tumor volumes, their spatial congruence, and the distance between the local hot spots were assessed. Results: For patients with glioma, TBR was significantly higher in F-18-FET PET than in rCBV maps (TBR, 2.28 +/- 0.99 vs. 1.62 +/- 1.13; P, 0.001). Histogram analysis of the VOIs revealed that F-18-FET scans could clearly separate tumor from background. In contrast, deriving this information from rCBV maps was difficult. Tumor volumes were significantly larger in F-18-FET PET than in rCBV maps (tumor volume, 24.3 +/- 26.5 cm(3) vs. 8.9 +/- 13.9 cm(3); P < 0.001). Accordingly, spatial overlap of both imaging parameters was poor (congruence, 11.0%), and mean distance between the local hot spots was 25.4 +/- 16.1 mm. In meningioma patients, TBR was higher in rCBV maps than in F-18-FET PET (TBR, 5.33 +/- 2.63 vs. 2.37 +/- 0.32; P < 0.001) whereas tumor volumes were comparable. Conclusion: In patients with cerebral glioma, tumor imaging with F-18-FET PET and rCBV yields different information. F-18-FET PET shows considerably higher TBRs and larger tumor volumes than rCBV maps. The spatial congruence of both parameters is poor. The locations of the local hot spots differ considerably. Taken together, our data show that metabolically active tumor tissue of gliomas as depicted by amino acid PET is not reflected by rCBV as measured with PWI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Filss, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Sabel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittsack, Hans J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Turowski, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Antoch, Gerald UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Ke UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Coenen, Heinz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herzog, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-442718
DOI:	10.2967/jnumed.113.129007
Journal or Publication Title:	J. Nucl. Med.
Volume:	55
Number:	4
Page Range:	S. 540 - 546
Date:	2014
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBRAL BLOOD-VOLUME; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; MICROVESSEL DENSITY; HISTOGRAM ANALYSIS; GRADE GLIOMAS; GLIOBLASTOMA; MAPS; IDENTIFICATION; HETEROGENEITY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44271