Universität zu Köln

Juergens, Jessica, Engel-Riedel, Walburga, Prickartz, Alexander, Ludwig, Corinna, Schildgen, Oliver ORCID: 0000-0003-4297-9627, Tillmann, Ramona-Liza, Stoelben, Erich, Brockmann, Michael and Schildgen, Verena (2014). Combined point mutation in KRAS or EGFR genes and EML4-ALK translocation in lung cancer patients. Future Oncol., 10 (4). S. 529 - 533. LONDON: FUTURE MEDICINE LTD. ISSN 1744-8301

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Abstract

A total of three cases with novel constellations regarding mutation patterns in non-small-cell lung cancer (NSCLC) are reported. The mutation patterns that are observed are novel and unexpected. First, a combined simultaneous KRAS mutation and EML4-ALK translocation, both in the main tumor and a bone metastasis, were observed, these mutations are assumed to mutually exclude each other. A further two cases include a father and a daughter, both of whom are suffering from NSCLC with different EGFR mutation patterns. A common cause was assumed; however, could not be deduced to mutations in the KRAS, BRAF and EGFR genes. The aforementioned cases are important, as it must be taken into account that mutations previously assumed to be exclusive can occur in combination, may influence the clinical outcome and may require different therapy compared with single mutated tumors. It has to be discussed whether diagnostic algorithms need to be adapted. The cases of father and daughter show that further unknown factors can influence development of NSCLC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Juergens, Jessica UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel-Riedel, Walburga UNSPECIFIED UNSPECIFIED UNSPECIFIED Prickartz, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Ludwig, Corinna UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED Tillmann, Ramona-Liza UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoelben, Erich UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-443977
DOI:	10.2217/FON.13.194
Journal or Publication Title:	Future Oncol.
Volume:	10
Number:	4
Page Range:	S. 529 - 533
Date:	2014
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1744-8301
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RESISTANCE; CRIZOTINIB; INHIBITORS; PATHOLOGY Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44397