Universität zu Köln

Huenseler, C., von Kries, R. and Roth, B. (2014). Decrease of the Incidence of Renin-Angiotensin-System Inhibitor Induced Oligohydramnios-Sequence in Germany in 2011. Klinische Padiatr., 226 (2). S. 59 - 62. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3824

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Abstract

Aim: to assess whether the incidence of angiotensin II-receptor type 1antagonist (AT1-anta-gonist) - or ACE-inhibitor induced cases of oligohydramnios sequence (OHS) in 2011 was reduced after intensive alerts as to the causal association between AT1-antagonist /ACE-inhibitor and OHS in the German medical literature. Method: 3 sources of information were used: A nationwide active surveillance of OHS in German paediatric hospitals (ESPED); Embryotox, (Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy) and screening of pubmed (AT1-antagonist/ACE-inhibitor induced OHS). Results: 45 cases of OHS were identified, no case due to maternal AT1-antagonist/ACE-inhibitor treatment. Causes for OHS were: premature rupture of membranes (PPROM) (n=28), congenital anomalies of fetal kidneys and urinary tract (CAKUT (n=15), placental insufficiency (n=1), unknown cause (n=1). Mortality until discharge was 37.8% (32.1% PPROM, 57.1% CAKUT). Embryotox identified 3 exposures to AT1-antagonists in pregnancy, no case was associated with OHS. The pubmed search did not identify any case of OHS related to AT1-antagonist/ACE-inhibitor in pregnancy in Germany in 2011. Conclusion: Treatment of pregnant women with ACE inhibitors or AT1-antagonists still occurs but no cases of AT1-antagonist- or ACE-inhibitor induced OHS were reported in 2011 in Germany most likely due to repeated published alerts underlining the importance of consequent education. OHS remains a serious condition with high mortality despite modern intensive care.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Huenseler, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Kries, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roth, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-444433
DOI:	10.1055/s-0033-1363267
Journal or Publication Title:	Klinische Padiatr.
Volume:	226
Number:	2
Page Range:	S. 59 - 62
Date:	2014
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3824
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language II-RECEPTOR BLOCKERS; PREGNANCY; FETOPATHY; EXPOSURE Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44443