Universität zu Köln

Luers, J. C., Sircar, K., Drebber, U. and Beutner, D. (2014). The impact of laryngeal dysplasia on the development of laryngeal squamous cell carcinoma. Eur. Arch. Oto-Rhino-Laryn., 271 (3). S. 539 - 546. NEW YORK: SPRINGER. ISSN 1434-4726

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Abstract

The aims of this study were to investigate the clinical course of patients with laryngeal dysplasia of various grades after surgical removal and analyze the percentage and time frame in which laryngeal dysplasia progresses to invasive carcinoma. The files of patients with surgical removal of laryngeal dysplasia and at least two microlaryngoscopies during a 10-year period were retrospectively reviewed. In total, 210 microlaryngoscopies of 70 adult patients were analyzed. Overall, of 295 biopsies taken 21 % showed no dysplastic alterations, 69 % showed dysplasia and 10 % showed invasive carcinoma, which had developed out of a laryngeal dysplasia. Dysplasia grades were equally distributed within the first three microlaryngoscopies (P = 0.31, P = 0.50, P = 0.55). The risk for developing laryngeal cancer out of laryngeal dysplasia showed no statistical correlation to the initial dysplasia grade (P = 0.26). On average, the malignant conversion took 127 weeks (mild dysplasia = 117 weeks; moderate dysplasia = 135 weeks; severe dysplasia = 82 weeks) (P = 0.27). Patients with laryngeal dysplasia are an inhomogeneous group and the grade of laryngeal dysplasia alone seems to be an insufficient prognostic factor for the development of laryngeal cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Luers, J. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sircar, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beutner, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-444935
DOI:	10.1007/s00405-013-2670-2
Journal or Publication Title:	Eur. Arch. Oto-Rhino-Laryn.
Volume:	271
Number:	3
Page Range:	S. 539 - 546
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1434-4726
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UPPER AERODIGESTIVE TRACT; EPITHELIAL CHANGES; IN-SITU; MANAGEMENT; LESIONS; CANCER; LEUKOPLAKIA; THERAPY; INSITU; RISK Multiple languages Otorhinolaryngology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44493