Universität zu Köln

Croxford, Andrew L., Karbach, Susanne, Kurschus, Florian C. ORCID: 0000-0001-7550-0681, Woertge, Simone, Nikolaev, Alexei, Yogev, Nir, Klebow, Sabrina, Schueler, Rebecca, Reissig, Sonja, Piotrowski, Carolin, Brylla, Elke, Bechmann, Ingo, Scheller, Juregen, Rose-John, Stefan ORCID: 0000-0002-7519-3279, Wunderlich, F. Thomas, Muenzel, Thomas ORCID: 0000-0001-5503-4150, von Stebut, Esther and Waisman, Ari ORCID: 0000-0003-4304-8234 (2014). IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions. J. Invest. Dermatol., 134 (3). S. 728 - 736. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-1747

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Abstract

The lack of a generally accepted animal model for human psoriasis has hindered progress with respect to understanding the pathogenesis of the disease. Here we present a model in which transgenic IL-17A expression is targeted to the skin in mice, achievable after crossing our IL-17A(ind) allele to the K14-Cre strain. K14-IL-17A(ind/+) mice invariably develop an overt skin inflammation bearing many hallmark characteristics of human psoriasis including dermal infiltration of effector T cells, formation of neutrophil nnicroabscesses, and hyperkeratosis. IL-17A expression in the skin results in upregulated granulopoiesis and migration of IL-6R-expressing neutrophils into the skin. Neutralization of IL-6 signaling efficiently reduces the observed pathogenesis in skin of IL-17A-overexpressing mice, with marked reductions in epidermal neutrophil abscess formation and epidermal thickening. Thus, IL-6 functions downstream of IL-17A to exacerbate neutrophil microabscess development in psoriasiform lesions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Croxford, Andrew L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karbach, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurschus, Florian C. UNSPECIFIED orcid.org/0000-0001-7550-0681 UNSPECIFIED Woertge, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Nikolaev, Alexei UNSPECIFIED UNSPECIFIED UNSPECIFIED Yogev, Nir UNSPECIFIED UNSPECIFIED UNSPECIFIED Klebow, Sabrina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schueler, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Reissig, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Piotrowski, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Brylla, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechmann, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheller, Juregen UNSPECIFIED UNSPECIFIED UNSPECIFIED Rose-John, Stefan UNSPECIFIED orcid.org/0000-0002-7519-3279 UNSPECIFIED Wunderlich, F. Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Muenzel, Thomas UNSPECIFIED orcid.org/0000-0001-5503-4150 UNSPECIFIED von Stebut, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Waisman, Ari UNSPECIFIED orcid.org/0000-0003-4304-8234 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-445417
DOI:	10.1038/jid.2013.404
Journal or Publication Title:	J. Invest. Dermatol.
Volume:	134
Number:	3
Page Range:	S. 728 - 736
Date:	2014
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-1747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language T-CELLS; HUMAN KERATINOCYTES; TH17 CELLS; RHEUMATOID-ARTHRITIS; PSORIATIC-ARTHRITIS; SKIN INFLAMMATION; INTERFERON-GAMMA; SERUM-LEVELS; IFN-GAMMA; INTERLEUKIN-17 Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44541