Universität zu Köln

Zhang, Ke, Langen, Karl-Josef ORCID: 0000-0003-1101-5075, Neuner, Irene ORCID: 0000-0002-5164-8873, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Filss, Christian ORCID: 0000-0002-9927-6335, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Tellmann, Lutz ORCID: 0000-0002-1154-2847, Kops, Elena Rota, Coenen, Heinz H., Herzog, Hans and Shah, Nadim J. (2014). Relationship of regional cerebral blood flow and kinetic behaviour of O-(2-F-18-fluoroethyl)-L-tyrosine uptake in cerebral gliomas. Nucl. Med. Commun., 35 (3). S. 245 - 252. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5628

Full text not available from this repository.

Abstract

ObjectivesO-(2-F-18-fluoroethyl)-l-tyrosine (F-18-FET) is an established tracer for brain tumour imaging. F-18-FET kinetics in gliomas appear to have potential for tumour grading, but the mechanisms remain unclear. The aim of this study was to explore the relationship between regional cerebral blood flow (rCBF) as measured by arterial spin labelling MRI and the kinetic behaviour of F-18-FET PET in cerebral gliomas.Materials and methodsTwenty patients with cerebral gliomas were investigated using arterial spin labelling MRI and dynamic F-18-FET PET. Time-activity curves (TACs) of F-18-FET uptake were analysed in 33 different tumour regions. The slopes of TAC during the early (0-5 min; slope(up)) and late phases of tracer uptake (17-50 min; slope(down)) were fitted using linear regression lines. In addition, TACs of each lesion were assigned to different curve patterns. Furthermore, we calculated tumour-to-brain ratios of F-18-FET uptake. The relationship between F-18-FET parameters and rCBF was determined.Results(18)F-FET uptake in the early phase (slope(up)) showed a significant correlation with rCBF (r=0.4; P=0.02). In contrast, both slope(down) and TAC patterns showed no significant correlation with rCBF. Furthermore, a significant correlation was found between rCBF and tumour-to-brain ratio (r=0.53; P=0.002).ConclusionThere is a relationship between rCBF and F-18-FET uptake in cerebral gliomas in the initial uptake phase, but the kinetic behaviour of F-18-FET uptake in the late phase is not significantly influenced by rCBF. Thus, the differential kinetic pattern of F-18-FET uptake in high-grade and low-grade gliomas appears to be determined by factors other than rCBF. (C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhang, Ke UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Neuner, Irene UNSPECIFIED orcid.org/0000-0002-5164-8873 UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Filss, Christian UNSPECIFIED orcid.org/0000-0002-9927-6335 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Tellmann, Lutz UNSPECIFIED orcid.org/0000-0002-1154-2847 UNSPECIFIED Kops, Elena Rota UNSPECIFIED UNSPECIFIED UNSPECIFIED Coenen, Heinz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herzog, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-445541
DOI:	10.1097/MNM.0000000000000036
Journal or Publication Title:	Nucl. Med. Commun.
Volume:	35
Number:	3
Page Range:	S. 245 - 252
Date:	2014
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1473-5628
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL-APPLICATIONS; F-18-FET PET; HUMAN BRAIN; FET PET; TRANSPORT; CONTRAST; DENSITY; MRI Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44554