Universität zu Köln

Ehren, K., Hertenstein, C., Kuemmerle, T., Vehreschild, J. J., Fischer, J., Gillor, D., Wyen, C., Lehmann, C., Cornely, O. A., Jung, N., Gravemann, S., Platten, M., Wasmuth, J. C., Rockstroh, J. K., Boesecke, C., Schwarze-Zander, C. and Faetkenheuer, G. (2014). Causes of death in HIV-infected patients from the Cologne-Bonn cohort. Infection, 42 (1). S. 135 - 141. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

Full text not available from this repository.

Abstract

Causes of death in human immunodeficiency virus (HIV)-infected subjects have changed in countries with high resources over the last several years. Acquired immunodeficiency syndrome (AIDS)-related diseases have become less prevalent, whereas deaths due to non-AIDS causes are increasing. The aim of the present study was to analyse causes of death in the Cologne-Bonn cohort. Causes of death from the Cologne-Bonn cohort between 2004 and 2010 were systematically recorded using the CoDe algorithm (The Coding Causes of Death in HIV Project). In 3,165 patients followed from 2004 to 2010, 182 deaths occurred (5.7 %, 153 males, 29 females). The median age at the time of death was 47 years (range 24-85 years). The most frequent causes of death were AIDS-defining events (n = 60, 33 %), with non-Hodgkin lymphoma (NHL) (n = 29, 16 %) and infections (n = 20, 11 %) being the leading entities in this category. Non-AIDS malignancies accounted for 16 % (n = 29), non-HIV-related infections for 10 % (n = 18), cardiovascular diseases for 7 % (n = 14), suicide or accident for 4 % (n = 7) and liver diseases for 3 % (n = 5) of deaths (unknown n = 47, 26 %). Although the majority of patients (92.5 %) was on antiretroviral therapy (ART), only 50 % were virologically suppressed (HIV-RNA < 50 copies/mL) and 44 % had a decreased CD4+ count (< 200/mu L) at their last visit before death. One-third of the causes of death in our cohort between 2004 and 2010 was AIDS-related. Since most of these deaths occur with severe immune suppression, they can possibly be prevented by the early diagnosis and treatment of HIV infection. Care providers must be aware of an increased risk for a broad range of diseases in HIV-infected patients and should apply appropriate preventive measures.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ehren, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hertenstein, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuemmerle, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, J. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gillor, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wyen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gravemann, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Platten, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wasmuth, J. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rockstroh, J. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boesecke, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarze-Zander, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-447076
DOI:	10.1007/s15010-013-0535-7
Journal or Publication Title:	Infection
Volume:	42
Number:	1
Page Range:	S. 135 - 141
Date:	2014
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-0973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-IMMUNODEFICIENCY-VIRUS; LIVER-RELATED MORTALITY; ALL-CAUSE MORTALITY; ANTIRETROVIRAL THERAPY; CANCER; ADULTS; INDIVIDUALS; SMOKING; RISK; AIDS Multiple languages Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44707