Abbas, S., Linseisen, J., Rohrmann, S., Beulens, J. W. J., Buijsse, B., Amiano, P., Ardanaz, E., Balkau, B., Boeing, H., Clavel-Chapelon, F., Fagherazzi, G., Franks, P. W., Gavrila, D., Grioni, S., Kaaks, R., Key, T. J., Khaw, K. T., Kuehn, T., Mattiello, A., Molina-Montes, E., Nilsson, P. M., Overvad, K., Quiros, J. R., Rolandsson, O., Sacerdote, C., Saieva, C., Slimani, N., Sluijs, I., Spijkerman, A. M. W., Tjonneland, A., Tumino, R., van der A, D. L., Zamora-Ros, R., Sharp, S. J., Langenberg, C., Forouhi, N. G., Riboli, E. and Wareham, N. J. (2014). Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study. Eur. J. Clin. Nutr., 68 (2). S. 196 - 203. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5640

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Abstract

BACKGROUND/OBJECTIVES: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. SUBJECTS/METHODS: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N = 15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N = 2347) were used to calibrate habitual intake data derived from dietary questionnaires. RESULTS: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (P-trend = 0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 mg/day dietary vitamin D. CONCLUSIONS: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Abbas, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linseisen, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rohrmann, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beulens, J. W. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buijsse, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amiano, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ardanaz, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balkau, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boeing, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clavel-Chapelon, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fagherazzi, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franks, P. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gavrila, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grioni, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaaks, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Key, T. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khaw, K. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuehn, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mattiello, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Molina-Montes, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nilsson, P. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Overvad, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quiros, J. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rolandsson, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sacerdote, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saieva, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slimani, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sluijs, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spijkerman, A. M. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tjonneland, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tumino, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der A, D. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zamora-Ros, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sharp, S. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langenberg, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forouhi, N. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riboli, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wareham, N. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-447570
DOI: 10.1038/ejcn.2013.235
Journal or Publication Title: Eur. J. Clin. Nutr.
Volume: 68
Number: 2
Page Range: S. 196 - 203
Date: 2014
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-5640
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
25-HYDROXYVITAMIN D CONCENTRATION; INSULIN-SECRETION; 1,25-DIHYDROXYVITAMIN D-3; CALCIUM; CALIBRATION; COHORT; METAANALYSIS; EXPRESSION; VALIDITY; PROJECTMultiple languages
Nutrition & DieteticsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44757

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