Universität zu Köln

Cornely, Oliver A., Vazquez, Jose, De Waele, Jan, Betts, Robert, Rotstein, Coleman, Nucci, Marcio ORCID: 0000-0003-4867-0014, Pappas, Peter G. and Ullmann, Andrew J. (2014). Efficacy of micafungin in invasive candidiasis caused by common Candida species with special emphasis on non-albicans Candida species. Mycoses, 57 (2). S. 79 - 90. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

The incidence of invasive candidiasis caused by non-albicans Candida (NAC) spp. is increasing. The aim of this analysis was to evaluate the efficacy of micafungin, caspofungin and liposomal amphotericin B in patients with invasive candidiasis and candidaemia caused by different Candida spp. This post hoc analysis used data obtained from two randomised phase III trials was conducted to evaluate the efficacy and safety of micafungin vs. caspofungin and micafungin vs. liposomal amphotericin B. Treatment success, clinical response, mycological response and mortality were evaluated in patients infected with C. albicans and NAC spp. Treatment success rates in patients with either C. albicans or NAC infections were similar. Outcomes were similar for micafungin, caspofungin and liposomal amphotericin B. Candida albicans was the most prevalent pathogen recovered (41.0%), followed by C. tropicalis (17.9%), C. parapsilosis (14.4%), C. glabrata (10.4%), multiple Candida spp. (7.3%) and C. krusei (3.2%). Age, primary diagnosis (i.e. candidaemia or invasive candidiasis), previous corticosteroid therapy and Acute Physiology and Chronic Health Evaluation II score were identified as potential predictors of treatment success and mortality. Micafungin, caspofungin and liposomal amphotericin B exhibit favourable treatment response rates that are comparable for patients infected with different Candida spp.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vazquez, Jose UNSPECIFIED UNSPECIFIED UNSPECIFIED De Waele, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Betts, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Rotstein, Coleman UNSPECIFIED UNSPECIFIED UNSPECIFIED Nucci, Marcio UNSPECIFIED orcid.org/0000-0003-4867-0014 UNSPECIFIED Pappas, Peter G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullmann, Andrew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-447779
DOI:	10.1111/myc.12104
Journal or Publication Title:	Mycoses
Volume:	57
Number:	2
Page Range:	S. 79 - 90
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLOOD-STREAM INFECTIONS; LIPOSOMAL AMPHOTERICIN-B; NON-NEUTROPENIC PATIENTS; INTENSIVE-CARE; RISK-FACTORS; EMPIRICAL-TREATMENT; FUNGAL-INFECTIONS; CLINICAL-TRIALS; UNITED-STATES; EPIDEMIOLOGY Multiple languages Dermatology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44777