Universität zu Köln

Roberts, Jacqueline M., Ennajdaoui, Hanane, Edmondson, Carina, Wirth, Brunhilde ORCID: 0000-0003-4051-5191, Sanford, Jeremy R. and Chen, Bin (2014). Splicing Factor TRA2B Is Required for Neural Progenitor Survival. J. Comp. Neurol., 522 (2). S. 372 - 393. HOBOKEN: WILEY. ISSN 1096-9861

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Abstract

Alternative splicing of pre-mRNAs can rapidly regulate the expression of large groups of proteins. The RNA binding protein TRA2B (SFRS10) plays well-established roles in developmentally regulated alternative splicing during Drosophila sexual differentiation. TRA2B is also essential for mammalian embryogenesis and is implicated in numerous human diseases. Precise regulation of alternative splicing is critical to the development and function of the central nervous system; however, the requirements for specific splicing factors in neurogenesis are poorly understood. This study focuses on the role of TRA2B in mammalian brain development. We show that, during murine cortical neurogenesis, TRA2B is expressed in both neural progenitors and cortical projection neurons. Using cortex-specific Tra2b mutant mice, we show that TRA2B depletion results in apoptosis of the neural progenitor cells as well as disorganization of the cortical plate. Thus, TRA2B is essential for proper development of the cerebral cortex. (c) 2013 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roberts, Jacqueline M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ennajdaoui, Hanane UNSPECIFIED UNSPECIFIED UNSPECIFIED Edmondson, Carina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirth, Brunhilde UNSPECIFIED orcid.org/0000-0003-4051-5191 UNSPECIFIED Sanford, Jeremy R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Bin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-448004
DOI:	10.1002/cne.23405
Journal or Publication Title:	J. Comp. Neurol.
Volume:	522
Number:	2
Page Range:	S. 372 - 393
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1096-9861
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRE-MESSENGER-RNA; SUBCORTICAL PROJECTION NEURONS; SR PROTEINS; FRONTOTEMPORAL DEMENTIA; SIGNAL INTERACTIONS; BINDING PROTEINS; GENE-EXPRESSION; CEREBRAL-CORTEX; DIFFERENTIATION; TAU Multiple languages Neurosciences; Zoology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44800