Universität zu Köln

Gloeckner, Gernot, Huelsmann, Norbert, Schleicher, Michael, Noegel, Angelika A., Eichinger, Ludwig ORCID: 0000-0003-1594-6117, Gallinger, Christoph, Pawlowski, Jan ORCID: 0000-0003-2421-388X, Sierra, Roberto ORCID: 0000-0002-8657-1781, Euteneuer, Ursula, Pillet, Loic, Moustafa, Ahmed ORCID: 0000-0002-0111-3555, Platzer, Matthias, Groth, Marco ORCID: 0000-0002-9199-8990, Szafranski, Karol and Schliwa, Manfred (2014). The Genome of the Foraminiferan Reticulomyxa filosa. Curr. Biol., 24 (1). S. 11 - 19. CAMBRIDGE: CELL PRESS. ISSN 1879-0445

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Abstract

Background: Rhizaria are a major branch of eukaryote evolution with an extensive microfossil record, but only scarce molecular data are available. The rhizarian species Reticulomyxa filosa, belonging to the Foraminifera, is free-living in freshwater environments. In culture, it thrives only as a plasmodium with thousands of haploid nuclei in one cell. The R. filosa genome is the first foraminiferal genome to be deciphered. Results: The genome is extremely repetitive, and the large amounts of identical sequences hint at frequent amplifications and homologous recombination events. Presumably, these mechanisms are employed to provide more gene copies for higher transcriptional activity and to build up a reservoir of gene diversification in certain gene families, such as the kinesin family. The gene repertoire indicates that it is able to switch to a single-celled, flagellated sexual state never observed in culture. Comparison to another rhizarian, the chlorarachniophyte alga Bigelowiella natans, reveals that proteins involved in signaling were likely drivers in establishing the Rhizaria lineage. Compared to some other protists, horizontal gene transfer is limited, but we found evidence of bacterial-to-eukaryote and eukaryote-to-eukaryote transfer events. Conclusions: The R. filosa genome exhibits a unique architecture with extensive repeat homogenization and gene amplification, which highlights its potential for diverse life-cycle stages. The ability of R. filosa to rapidly transport matter from the pseudopodia to the cell body may be supported by the high diversification of actin and kinesin gene family members.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gloeckner, Gernot UNSPECIFIED UNSPECIFIED UNSPECIFIED Huelsmann, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Schleicher, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Noegel, Angelika A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichinger, Ludwig UNSPECIFIED orcid.org/0000-0003-1594-6117 UNSPECIFIED Gallinger, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Pawlowski, Jan UNSPECIFIED orcid.org/0000-0003-2421-388X UNSPECIFIED Sierra, Roberto UNSPECIFIED orcid.org/0000-0002-8657-1781 UNSPECIFIED Euteneuer, Ursula UNSPECIFIED UNSPECIFIED UNSPECIFIED Pillet, Loic UNSPECIFIED UNSPECIFIED UNSPECIFIED Moustafa, Ahmed UNSPECIFIED orcid.org/0000-0002-0111-3555 UNSPECIFIED Platzer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Groth, Marco UNSPECIFIED orcid.org/0000-0002-9199-8990 UNSPECIFIED Szafranski, Karol UNSPECIFIED UNSPECIFIED UNSPECIFIED Schliwa, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-448722
DOI:	10.1016/j.cub.2013.11.027
Journal or Publication Title:	Curr. Biol.
Volume:	24
Number:	1
Page Range:	S. 11 - 19
Date:	2014
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1879-0445
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENE-TRANSFER; DICTYOSTELIUM-DISCOIDEUM; ORGANELLE TRANSPORT; EVOLUTION; AMEBA; IDENTIFICATION; TRANSCRIPTOME; ANNOTATION; ALIGNMENT; PROFILES Multiple languages Biochemistry & Molecular Biology; Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44872