Universität zu Köln

Nourollahi, Sabrina, Wille, Julia, Weiss, Verena, Wedekind, Christoph and Lippert-Gruener, Marcela (2014). Quality-of-life in patients with post-traumatic hypopituitarism. Brain Inj., 28 (11). S. 1425 - 1430. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1362-301X

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Abstract

Primary objective: Hypopituitarism is a frequent complication in patients after traumatic brain injury (TBI). Both TBI and hypopituitarism can lead to complex cognitive and affective deficits. This study was intended to examine the quality-of-life in patients with post-traumatic hypopituitarism (PTH) and to discern the effect of this endocrinological disorder on general outcome of patients after TBI including earning capacity. Research type: Retrospective analysis of clinical data. Methods and procedures: Ninety-seven symptomatic patients were screened after TBI for PTH. Their results were examined in the SF-36 [a standardized questionnaire for quality of life (QoL)] comparing the groups with or without PTH. After 6 months of hormone substitution (if necessary), patients were asked to repeat the SF-36. Main outcomes and results: Forty-six patients were diagnosed with PTH (47.5%). All patients included had a significantly lower QoL compared to the standard population. QoL was significantly worse in patients with PTH. There was no significant difference with regard to earning capacity. After hormone substitution, patients achieved better SF-36-results, albeit the difference was lacking statistical significance. Conclusions: PTH is frequent after TBI. PTH turns out to further diminish QoL, without affecting earning capacity. Hormone substitution might improve QoL in patients with PTH, but future research is needed to confirm this hypothesis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nourollahi, Sabrina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wille, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Wedekind, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Lippert-Gruener, Marcela UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-449644
DOI:	10.3109/02699052.2014.917201
Journal or Publication Title:	Brain Inj.
Volume:	28
Number:	11
Page Range:	S. 1425 - 1430
Date:	2014
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1362-301X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRAUMATIC BRAIN-INJURY; GROWTH-HORMONE REPLACEMENT; SUBARACHNOID HEMORRHAGE; PITUITARY DYSFUNCTION; HEALTH-STATUS; MODERATE; RETURN; WORK; INSUFFICIENCY; DEPRESSION Multiple languages Neurosciences; Rehabilitation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44964