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Hagmann, Henning, Shankland, Stuart J. and Brinkkoetter, Paul T. (2014). Cell Cycle and Podocyte Injury. In: Contributions to Nephrology, S. 12 - 22. BASEL: KARGER. ISBN 978-3-318-02651-1; 978-3-318-02650-4

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Abstract

Background: The cell cycle is regulated by cyclins activating cyclin-dependent kinases (Cdk). Cdk inhibitors bind to and inhibit cyclin-Cdk complexes. The complex interplay between these cell cycle regulatory proteins governs the fate of podocytes when under stress induced by disease. Summary: The development of the normal podocyte is likely not dependent on one particular cell cycle protein. There is even some redundancy for certain cyclin-dependent kinase (Cdk) inhibitors. Adult podocytes constitutively express several cell cycle proteins including cyclins D1 and I, Cdk5, and the Cdk inhibitors p27 and p57. Adult podocytes have a very limited proliferative capacity because DNA synthesis is prevented due to increases in the Cdk inhibitors p21, p27 and p57, which bind to and inhibit cyclin A-Cdk2 complexes. Cdk inhibitors also regulate the threshold to podocyte apoptosis, and p21 also underlies their hypertrophic response to injury. Specific cell cycle proteins are essential for podocyte survival following stress. In particular, the activation of Cdk5 by cyclin I and p35 play vital roles in limiting apoptosis, and therefore in the maintenance of podocyte number. Key Messages: Following disease-induced stress, cell cycle proteins regulate adult podocyte proliferation, apoptosis and size, and in doing so, critically govern the fate of these terminally differentiated epithelial cells in disease. (C) 2014 S. Karger AG, Basel

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Hagmann, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Shankland, Stuart J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinkkoetter, Paul T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-449727
DOI:	10.1159/000360504
Title of Book:	Contributions to Nephrology
Series Name:	Contrib.Nephrol.
Volume:	183
Page Range:	S. 12 - 22
Date:	2014
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	0302-5144
ISBN:	978-3-318-02651-1; 978-3-318-02650-4
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIV-ASSOCIATED NEPHROPATHY; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; IN-VITRO; COLLAPSING GLOMERULOPATHY; PROTECTS PODOCYTES; KINASE INHIBITORS; TRANSGENIC MICE; RENAL-DISEASE; PROLIFERATION; EXPRESSION Multiple languages Cell Biology; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44972