Universität zu Köln

Ersoy, Lebriz, Ristau, Tina, Lechanteur, Yara T., Hahn, Moritz, Hoyng, Carel B., Kirchhof, Bernd, den Hollander, Anneke I. and Fauser, Sascha (2014). Nutritional Risk Factors for Age-Related Macular Degeneration. Biomed Res. Int., 2014. LONDON: HINDAWI LTD. ISSN 2314-6141

Full text not available from this repository.

Abstract

Purpose. To evaluate the role of nutritional factors, serum lipids, and lipoproteins in late age-related macular degeneration (late AMD). Methods. Intake of red meat, fruit, fish, vegetables, and alcohol, smoking status, and body mass index (BMI) were ascertained questionnaire-based in 1147 late AMD cases and 1773 controls from the European Genetic Database. Serum levels of lipids and lipoproteins were determined. The relationship between nutritional factors and late AMD was assessed using logistic regression. Based on multivariate analysis, area-under-the-curve (AUC) was calculated by receiver-operating-characteristics (ROC). Results. In a multivariate analysis, besides age and smoking, obesity (odds ratio (OR): 1.44, P = 0.014) and red meat intake (daily: OR: 2.34, P = 8.22 x 10(-6); 2-6x/week: OR: 1.67, P = 7.98 x 10(-5)) were identified as risk factors for developing late AMD. Fruit intake showed a protective effect (daily: OR: 0.52, P = 0.005; 2-6x/week: OR: 0.58, P = 0.035). Serum lipid and lipoprotein levels showed no significant association with late AMD. ROC for nutritional factors, smoking, age, and BMI revealed an AUC of 0.781. Conclusion. Red meat intake and obesity were independently associated with increased risk for late AMD, whereas fruit intake was protective. A better understanding of nutritional risk factors is necessary for the prevention of AMD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ersoy, Lebriz UNSPECIFIED UNSPECIFIED UNSPECIFIED Ristau, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Lechanteur, Yara T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED den Hollander, Anneke I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450037
DOI:	10.1155/2014/413150
Journal or Publication Title:	Biomed Res. Int.
Volume:	2014
Date:	2014
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2314-6141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIETARY-FAT; CONSUMPTION; MEAT; NEOVASCULARIZATION; PREVENTION; LOCI; RED Multiple languages Biotechnology & Applied Microbiology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45003