Universität zu Köln

Klemm, Christoph, Dommisch, Henrik, Goeke, Friederike, Kreppel, Matthias, Jepsen, Soren, Rolf, Fimmers, Dommisch, Klaus, Perner, Sven and Standop, Jens (2014). Expression profiles for 14-3-3 zeta and CCL20 in pancreatic cancer and chronic pancreatitis. Pathol. Res. Pract., 210 (6). S. 335 - 342. MUNICH: ELSEVIER GMBH. ISSN 0344-0338

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Abstract

Background: Pancreatic cancer (PCA) has a dismal prognosis because it is often diagnosed at an advanced stage. The overall survival rate is < 5% after five years. Chronic pancreatitis (CP) is one of the most important risk factors for PCA. A major difficulty is to distinguish between CF and PCA at both clinical and morphologic level. The aim of this study was to assess the impact of the expression profiles for 14-3-3 zeta and CCL20 to histologically discriminate between PCA and CP. Methods: In PCA (n = 138) and CF (n = 36) tissue samples, the expression of 14-3-3 zeta and CCL20 was examined by immunohistochemistry. Associations between expression profiles of 14-3-3 zeta and CCL20 expression in PCA, CP as well as MANT (matched adjacent normal tissue) (n = 138) and clinicopathologic variables were analyzed. Results: The expression of CCL20 and 14-3-3 zeta was significantly higher in PCA than in CP and MANT. For CF compared to MANT, no significant differences were observed for expression profiles of both 14-3-3 zeta and CCL20. Conclusion: CCL20 and 14-3-3 zeta are molecules that play a putative role during tumorgenesis in pancreas, and may therefore be new parameters for histological diagnosis and discrimination between PCA and CP. (C) 2014 Elsevier GmbH. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klemm, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Dommisch, Henrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeke, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Jepsen, Soren UNSPECIFIED UNSPECIFIED UNSPECIFIED Rolf, Fimmers UNSPECIFIED UNSPECIFIED UNSPECIFIED Dommisch, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Perner, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Standop, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450381
DOI:	10.1016/j.prp.2014.01.001
Journal or Publication Title:	Pathol. Res. Pract.
Volume:	210
Number:	6
Page Range:	S. 335 - 342
Date:	2014
Publisher:	ELSEVIER GMBH
Place of Publication:	MUNICH
ISSN:	0344-0338
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RISK-FACTORS; DIFFERENTIAL-DIAGNOSIS; THERAPEUTIC TARGET; CHEMOKINE CCL20; RECEPTOR; CCR6; ADENOCARCINOMA; PROTEIN; MIP-3-ALPHA/CCL20; 14-3-3-PROTEINS Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45038