Universität zu Köln

Moro, Nives, Mauch, Cornelia and Zigrino, Paola ORCID: 0000-0002-7470-0064 (2014). Metalloproteinases in melanoma. Eur. J. Cell Biol., 93 (1-2). S. 23 - 30. MUNICH: ELSEVIER GMBH. ISSN 1618-1298

Full text not available from this repository.

Abstract

Tumour cell adhesion, motility, proteolytic activities and cell receptors have important roles in cancer invasion. These processes are involved from early development of melanoma within the epidermis, to tumour cell invasion of the underlying tissue until intravasation of lymphatic or blood vessels, and thereafter, dissemination into distant organs occur. The activity of several proteolytic enzymes was shown to be pivotal in promoting melanoma cell invasion. These enzymes not only remodel the extracellular matrix, but also release active factors and shed cell surface receptors thereby mediating melanoma cross-communication with their microenvironment. This leads to the generation of a favourable environment for melanoma growth. Several proteases are involved in melanoma invasion and include serine, cysteine proteases, matrix metalloproteases (MMPs) and the disintegrin and metalloproteases (ADAMs). This study summarises the current knowledge on the role of metalloproteinases, MMPs and ADAMs, in melanoma. (C) 2014 Elsevier GmbH. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moro, Nives UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauch, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Zigrino, Paola UNSPECIFIED orcid.org/0000-0002-7470-0064 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450477
DOI:	10.1016/j.ejcb.2014.01.002
Journal or Publication Title:	Eur. J. Cell Biol.
Volume:	93
Number:	1-2
Page Range:	S. 23 - 30
Date:	2014
Publisher:	ELSEVIER GMBH
Place of Publication:	MUNICH
ISSN:	1618-1298
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MATRIX METALLOPROTEINASES; PATHOLOGICAL NEOVASCULARIZATION; COLLAGENASE ACTIVITY; DISINTEGRIN DOMAIN; FAMILY REVEALS; SECRETED FORM; IN-VITRO; EXPRESSION; INVASION; CELLS Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45047