Universität zu Köln

Ristau, Tina, Ersoy, Lebriz, Lechanteur, Yara ORCID: 0000-0003-0951-4625, den Hollander, Anneke I., Daha, Mohamed R., Hahn, Moritz, Hoyng, Carel B. and Fauser, Sascha (2014). Allergy Is a Protective Factor Against Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci., 55 (1). S. 210 - 215. ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. ISSN 1552-5783

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Abstract

PURPOSE. To investigate the role of allergy on AMD. METHODS. Age-related macular degeneration staging was performed for 3585 individuals (1878 from Cologne, Germany, and 1707 from Nijmegen, The Netherlands). Interviewer-assisted questionnaires were evaluated for the factors smoking, use of corticosteroids, and history of allergy, including causative allergens. Serum complement component C3d and C3 levels were measured and the C3d:C3 ratio was calculated. Associations of allergy with AMD/late AMD were assessed by logistic regression analysis; C3d:C3 ratio was compared between groups. RESULTS. The discovery cohort from Cologne included 864 AMD patients and 1014 controls; 495 patients had late AMD. Positive history of allergy showed strong protective effects on the phenotype AMD (OR 0.52; P = 3.42 x 10(-9)) and late AMD (OR 0.32; P x 2.57 X 10(-13)). Subclassification in allergy-provoking agents showed significant protective effects in all groups. After adjustment for age, sex, smoking, and corticosteroid use, protective effects for AMD (OR 0.75; P = 0.018) and late AMD (OR 0.49; P = 2.87 x 10(-5)) were confirmed. Although the C3d: C3 ratio was higher in AMD/late AMD patients (both P < 0.001), there was no association with allergy in AMD (P = 0.22). The protective effect of allergy on AMD was confirmed in the replication cohort from Nijmegen (P = 0.002 for AMD; P = 0.0001 for late AMD). CONCLUSIONS. Allergy has a protective effect on the development of AMD independent of the provoking allergen, which cannot be explained by complement activation. Further investigations are necessary to elucidate the molecular mechanisms underlying the protective effect of allergy on AMD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ristau, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ersoy, Lebriz UNSPECIFIED UNSPECIFIED UNSPECIFIED Lechanteur, Yara UNSPECIFIED orcid.org/0000-0003-0951-4625 UNSPECIFIED den Hollander, Anneke I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Daha, Mohamed R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450747
DOI:	10.1167/iovs.13-13248
Journal or Publication Title:	Invest. Ophthalmol. Vis. Sci.
Volume:	55
Number:	1
Page Range:	S. 210 - 215
Date:	2014
Publisher:	ASSOC RESEARCH VISION OPHTHALMOLOGY INC
Place of Publication:	ROCKVILLE
ISSN:	1552-5783
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYSTEMIC COMPLEMENT ACTIVATION; NLRP3 INFLAMMASOME ACTIVATION; RISK; COMPONENTS; VARIANT; ASTHMA; CELLS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45074