Universität zu Köln

Naehrlich, Lutz ORCID: 0000-0002-7146-6997, Ballmann, Manfred, Davies, Jane ORCID: 0000-0003-3506-1199, Derichs, Nico, Gonska, Tanja ORCID: 0000-0001-6786-4354, Hjelte, Lena, van Konigsbruggen-Rietschel, Silke, Leal, Teresinha, Melotti, Paola ORCID: 0000-0002-5276-1595, Middleton, Peter, Tuemmler, Burkhard, Vermeulen, Francois and Wilschanski, Michael (2014). Nasal potential difference measurements in diagnosis of cystic fibrosis: An international survey. J. Cyst. Fibros, 13 (1). S. 24 - 29. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-5010

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Abstract

Background: The role of nasal potential difference (NPD) measurement as a diagnostic test for cystic fibrosis (CF) is a subject of global controversy because of the lack of validation studies, clear reference values, and standardized protocols for diagnostic NPD. Methods: To determine diagnostic NPD frequency, protocols, interpretation, and rater agreement, we surveyed the 18 NPD centres of the European Cystic Fibrosis Society Diagnostic Network Working Group. Results: Fifteen centres reported performing 373 diagnostic NPDs in 2012. Most use the CFF-TDN-SCIP (67%) and the chloride-free + isoproterenol response of the side with the largest response (47%) as diagnostic criteria and use centre-specific reference ranges. Rater agreement for five NPD tracings in general was good, but poor in tracings with different responses between the two nostrils. Conclusions: NPD is frequently used as a diagnostic and research tool for CF. Performance is highly standardized, centre-specific reference ranges are established, and rater agreement in general is good. Centre-independent diagnostic criteria and reference ranges must be defined by multicentre validation studies to improve standardized interpretation for diagnostic use. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Naehrlich, Lutz UNSPECIFIED orcid.org/0000-0002-7146-6997 UNSPECIFIED Ballmann, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Davies, Jane UNSPECIFIED orcid.org/0000-0003-3506-1199 UNSPECIFIED Derichs, Nico UNSPECIFIED UNSPECIFIED UNSPECIFIED Gonska, Tanja UNSPECIFIED orcid.org/0000-0001-6786-4354 UNSPECIFIED Hjelte, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED van Konigsbruggen-Rietschel, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Leal, Teresinha UNSPECIFIED UNSPECIFIED UNSPECIFIED Melotti, Paola UNSPECIFIED orcid.org/0000-0002-5276-1595 UNSPECIFIED Middleton, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Tuemmler, Burkhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Vermeulen, Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilschanski, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-451109
DOI:	10.1016/j.jcf.2013.08.006
Journal or Publication Title:	J. Cyst. Fibros
Volume:	13
Number:	1
Page Range:	S. 24 - 29
Date:	2014
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1873-5010
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SWEAT TEST; GUIDELINES; PROTOCOLS; CHLORIDE Multiple languages Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45110