Universität zu Köln

Zhao, Bin ORCID: 0000-0002-0987-4586, Shen, Jianlei, Chen, Shixing, Wang, Dongfang, Li, Fan ORCID: 0000-0001-8582-4911, Mathur, Sanjay, Song, Shiping and Fan, Chunhai ORCID: 0000-0002-7171-7338 (2014). Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules. Chem. Sci., 5 (11). S. 4460 - 4467. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 2041-6539

Full text not available from this repository.

Abstract

Surface-enhanced Raman scattering (SERS) has recently been used to design novel nanoprobes called SERS tags which hold great promise for the fields of biosensing and nanomedicine. More recent advances have shed new light on the synthesis of uniform nanostructures with interior nanogaps for stable SERS enhancement. However, producing interior nanogap-based SERS nanotags directly and controllably with strong and stable multiplex SERS signals as well as developing a multiplex analytical platform to recognize different types of bioactive molecules still remain highly challenging. To address this challenge, we herein develop a novel approach for the direct synthesis of nanogap-based universal SERS nanotags by mediating poly-adenine (polyA) and encoding non-fluorescent small molecules. The universal nanotags were then functionalized by different types of biological probes and used as SERS nanoprobes to recognize various bioactive molecules. To the best of our knowledge, this is the first example of using SERS nanotags to develop a simultaneous multianalysis platform for all of the major types of bioactive analytes, including nucleic acids, proteins and small molecules. Furthermore, the nanotags show great promise for fluorescence-SERS bimodal bioanalysis and bioimaging.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhao, Bin UNSPECIFIED orcid.org/0000-0002-0987-4586 UNSPECIFIED Shen, Jianlei UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Shixing UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Dongfang UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Fan UNSPECIFIED orcid.org/0000-0001-8582-4911 UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Shiping UNSPECIFIED UNSPECIFIED UNSPECIFIED Fan, Chunhai UNSPECIFIED orcid.org/0000-0002-7171-7338 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-451871
DOI:	10.1039/c4sc01792g
Journal or Publication Title:	Chem. Sci.
Volume:	5
Number:	11
Page Range:	S. 4460 - 4467
Date:	2014
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	2041-6539
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENHANCED RAMAN-SCATTERING; SINGLE-STRANDED-DNA; OPTICAL NANOPROBES; CANCER-DETECTION; OVARIAN-CANCER; NANOPARTICLES; HYBRIDIZATION; SPECTROSCOPY; NUCLEOSIDES; BIOMARKERS Multiple languages Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/45187