Universität zu Köln

Maleki, Mahboubeh ORCID: 0000-0001-5746-4736, Amani-Tehran, Mohammad, Latifi, Masoud ORCID: 0000-0002-0030-9919 and Mathur, Sanjay (2014). Drug release profile in core-shell nanofibrous structures: A study on Peppas equation and artificial neural network modeling. Comput. Meth. Programs Biomed., 113 (1). S. 92 - 101. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-7565

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Abstract

Release profile of drug constituent encapsulated in electrospun core-shell nanofibrous mats was modeled by Peppas equation and artificial neural network. Core-shell fibers were fabricated by co-axial electrospinning process using tetracycline hydrochloride (TCH) as the core and poly(L-lactide-co-glycolide) (PLGA) or polycaprolactone (PCL) as the shell materials. The density and hydrophilicity of the shell polymers, feed rates and concentrations of core and shell phases, the contribution of TCH in core material and electrical field were the parameters fed to the perceptron network to predict Peppas constants in order to derive release pattern. This study demonstrated the viability of the prediction tool in determining drug release profile of electrospun core-shell nanofibrous scaffolds. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maleki, Mahboubeh UNSPECIFIED orcid.org/0000-0001-5746-4736 UNSPECIFIED Amani-Tehran, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Latifi, Masoud UNSPECIFIED orcid.org/0000-0002-0030-9919 UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-451967
DOI:	10.1016/j.cmpb.2013.09.003
Journal or Publication Title:	Comput. Meth. Programs Biomed.
Volume:	113
Number:	1
Page Range:	S. 92 - 101
Date:	2014
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-7565
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRAFINE FIBERS; POLYETHYLENE OXIDE; DELIVERY; OPTIMIZATION; TETRACYCLINE; DIAMETER Multiple languages Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods; Engineering, Biomedical; Medical Informatics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/45196