Universität zu Köln

Schloesser, Hans Anton, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Shimabukuro-Vornhagen, Alexander ORCID: 0000-0002-2351-7294, Holtick, Udo, Stippel, Dirk Ludger and von Bergwelt-Baildon, Michael (2014). Overcoming tumor-mediated immunosuppression. Immunotherapy, 6 (9). S. 973 - 989. LONDON: FUTURE MEDICINE LTD. ISSN 1750-7448

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Abstract

Mechanisms of tumor-mediated immunosuppression have been described for several solid and hematological tumors. Tumors inhibit immune responses by attraction of immunosuppressive lymphocytic populations, secretion of immunosuppressive cytokines or expression of surface molecules, which inhibit immune responses by induction of anergy or apoptosis in tumor-infiltrating lymphocytes. This tumor-mediated immunosuppression represents a major obstacle to many immunotherapeutic or conventional therapeutic approaches. In this review we discuss how tumor-mediated immunosuppression interferes with different immunotherapeutic approaches and then give an overview of strategies to overcome it. Particular emphasis is placed on agents or approaches already transferred into clinical settings. Finally the success of immune checkpoint inhibitors targeting CTLA-4 or the PD-1 pathway highlights the enormous therapeutic potential of an effective overcoming of tumor-mediated immunosuppression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schloesser, Hans Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Theurich, Sebastian UNSPECIFIED orcid.org/0000-0001-5706-8258 UNSPECIFIED Shimabukuro-Vornhagen, Alexander UNSPECIFIED orcid.org/0000-0002-2351-7294 UNSPECIFIED Holtick, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Stippel, Dirk Ludger UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-452277
DOI:	10.2217/imt.14.58
Journal or Publication Title:	Immunotherapy
Volume:	6
Number:	9
Page Range:	S. 973 - 989
Date:	2014
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1750-7448
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REGULATORY T-CELLS; CLASS-I ANTIGEN; INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION; PROGRAMMED DEATH-1 LIGAND-1; SINGLE-CHAIN ANTIBODY; NATURAL-KILLER-CELL; DOWN-REGULATION; B-CELLS; INFILTRATING LYMPHOCYTES; PROCESSING MACHINERY Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45227