Universität zu Köln

Dias, Irundika H. K., Polidori, Maria Cristina, Li, Li, Weber, Daniela ORCID: 0000-0002-2054-6233, Stahl, Wilhelm, Nelles, Gereon, Grune, Tilman ORCID: 0000-0003-4775-9973 and Griffiths, Helen R. ORCID: 0000-0002-2666-2147 (2014). Plasma Levels of HDL and Carotenoids are Lower in Dementia Patients with Vascular Comorbidities. J. Alzheimers Dis., 40 (2). S. 399 - 409. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Elevated serum cholesterol concentrations in mid-life increase risk for Alzheimer's disease (AD) in later life. However, lower concentrations of cholesterol-carrying high density lipoprotein (HDL) and its principal apolipoprotein A1 (ApoA1) correlate with increased risk for AD. As HDL transports oxocarotenoids, which are scavengers of peroxynitrite, we have investigated the hypothesis that lower HDL and oxocarotenoid concentrations during AD may render HDL susceptible to nitration and oxidation and in turn reduce the efficiency of reverse cholesterol transport (RCT) from lipid-laden cells. Fasting blood samples were obtained from subjects with 1) AD without cardiovascular comorbidities and risk factors (AD); 2) AD with cardiovascular comorbidities and risk factors (AD Plus); 3) normal cognitive function; for carotenoid determination by HPLC, analysis of HDL nitration and oxidation by ELISA, and H-3-cholesterol export to isolated HDL. HDL concentration in the plasma from AD Plus patients was significantly lower compared to AD or control subject HDL levels. Similarly, lutein, lycopene, and zeaxanthin concentrations were significantly lower in AD Plus patients compared to those in control subjects or AD patients, and oxocarotenoid concentrations correlated with Mini-Mental State Examination scores. At equivalent concentrations of ApoA1, HDL isolated from all subjects irrespective of diagnosis was equally effective at mediating RCT. HDL concentration is lower in AD Plus patients' plasma and thus capacity for RCT is compromised. In contrast, HDL from patients with AD-only was not different in concentration, modifications, or function from HDL of healthy age-matched donors. The relative importance of elevating HDL alone compared with elevating carotenoids alone or elevating both to reduce risk for dementia should be investigated in patients with early signs of dementia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dias, Irundika H. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Polidori, Maria Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Li UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Daniela UNSPECIFIED orcid.org/0000-0002-2054-6233 UNSPECIFIED Stahl, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Nelles, Gereon UNSPECIFIED UNSPECIFIED UNSPECIFIED Grune, Tilman UNSPECIFIED orcid.org/0000-0003-4775-9973 UNSPECIFIED Griffiths, Helen R. UNSPECIFIED orcid.org/0000-0002-2666-2147 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-452366
DOI:	10.3233/JAD-131964
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	40
Number:	2
Page Range:	S. 399 - 409
Date:	2014
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language APOLIPOPROTEIN-A-I; REVERSE CHOLESTEROL TRANSPORT; ALZHEIMERS-DISEASE; ANTIOXIDANT STATUS; BETA-CAROTENE; VITAMIN-C; OXIDATION; NITRATION; EFFLUX; ABCA1 Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45236