Universität zu Köln

Tevoufouet, Etienne E., Nembo, Erastus N., Dibue-Adjei, Maxine, Hescheler, Juergen, Nguemo, Filomain and Schneider, Toni (2014). Cardiac Functions of Voltage-Gated Ca2+ Channels: Role of the Pharmacoresistant Type (E-/R-Type) in Cardiac Modulation and Putative Implication in Sudden Unexpected Death in Epilepsy (SUDEP). In: Reviews of Physiology Biochemistry and Pharmacology, S. 115 - 140. BERLIN: SPRINGER-VERLAG BERLIN. ISBN 978-3-319-11921-2; 978-3-319-11920-5

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Abstract

Voltage-gated Ca2+ channels (VGCCs) are ubiquitous in excitable cells. These channels play key roles in many physiological events like cardiac regulation/ pacemaker activity due to intracellular Ca2+ transients. In the myocardium, the Cayl subfamily (L-type: C41.2 and C41.3) is the main contributor to excitation contraction coupling and/or pacemaking, whereas the Ca(v)3 subfamily (T-type: Cay3.1 and Cay3.2) is important in rhythmically firing of the cardiac nodal cells. No established cardiac function has been attributed to the Ca(v)2 family (E-/R-type: Ca(v)2.3) despite accumulating evidence of cardiac dysregulation observed upon deletion of the Ca(v)2.3 gene, the only member of this family so far detected in cardiomyocytes. In this review, we summarize the pathophysiological changes observed after ablation of the E-/R-type VGCC and propose a cardiac mechanism of action for this channel. Also, considering the role played by this channel in epilepsy and its reported sensitivity to antiepileptic drugs, a putative involvement of this channel in the cardiac mechanism of sudden unexpected death in epilepsy is also discussed.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Tevoufouet, Etienne E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nembo, Erastus N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dibue-Adjei, Maxine UNSPECIFIED UNSPECIFIED UNSPECIFIED Hescheler, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Nguemo, Filomain UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Toni UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-452693
DOI:	10.1007/112_2014_21
Title of Book:	Reviews of Physiology Biochemistry and Pharmacology
Series Name:	Rev. Physiol. Biochem. Pharmacol.
Volume:	167
Page Range:	S. 115 - 140
Date:	2014
Publisher:	SPRINGER-VERLAG BERLIN
Place of Publication:	BERLIN
ISSN:	0303-4240
ISBN:	978-3-319-11921-2; 978-3-319-11920-5
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language II-III LOOP; CA(V)2.3 ALPHA-1E SUBUNIT; CALCIUM-CHANNELS; R-TYPE; MICE LACKING; HEART-RATE; IONIC CURRENTS; BETA-SUBUNITS; MOUSE MODEL; EXPRESSION Multiple languages Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45269